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Details on Person ERBB2 homodimer phosphorylates SHC1

Class:Id	Reaction:9634390
_displayName	ERBB2 homodimer phosphorylates SHC1
_doRelease	TRUE
_timestamp	2019-11-12 18:15:27
authored	[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
catalystActivity	[CatalystActivity:9634396] protein tyrosine kinase activity of p-ERBB2 homodimer:SHC1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9634387] Orlic-Milacic, Marija, 2019-01-10
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9655466] increased_translational_product_level of p-ERBB2 homodimer:SHC1 [plasma membrane]
input	[Complex:9634389] p-ERBB2 homodimer:SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
modified	[InstanceEdit:9634401] Orlic-Milacic, Marija, 2019-01-10 [InstanceEdit:9634408] Orlic-Milacic, Marija, 2019-01-10 [InstanceEdit:9655473] Orlic-Milacic, Marija, 2019-07-24 [InstanceEdit:9655805] Orlic-Milacic, Marija, 2019-07-26 [InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23 [InstanceEdit:9665326] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 homodimer phosphorylates SHC1
normalReaction	[Reaction:1250195] SHC1 phosphorylation by ERBB2 heterodimers [Homo sapiens]
output	[Complex:9634399] p-ERBB2 homodimer:p-Y349,Y350-SHC1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9634391] SHC1 binds phosphorylated ERBB2 homodimer [Homo sapiens] [Reaction:1248694] Trans-autophosphorylation of ERBB2 homodimer [Homo sapiens]
releaseDate	2019-12-10
reviewed	[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9634394] R-HSA-9634390.2
summation	[Summation:9634405] While phosphorylation of SHC1 upon binding to homodimers of ...
(hasEvent)	[Pathway:9634285] Constitutive Signaling by Overexpressed ERBB2 [Homo sapiens]
(precedingEvent)	[Reaction:9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 homodimer phosphorylates SHC1 (9634390)