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Details on Person Eif2ak4 dimer autophosphorylates

Class:Id	Reaction:9633741
_displayName	Eif2ak4 dimer autophosphorylates
_doRelease	TRUE
_timestamp	2019-11-20 13:51:55
authored	[InstanceEdit:9633725] May, Bruce, 2018-12-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9633796] May, Bruce, 2018-12-30
edited	[InstanceEdit:9633725] May, Bruce, 2018-12-29
inferredFrom	[Reaction:9633750] GCN2 dimer autophosphorylates [Saccharomyces cerevisiae]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9633566] tRNA:Eif2ak4:Gcn1:80S ribosome:mRNA [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9633736] Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 [LiteratureReference:9633863] Activation of GCN2 in UV-irradiated cells inhibits translation [LiteratureReference:9633883] Regulated translation initiation controls stress-induced gene expression in mammalian cells
modified	[InstanceEdit:9633885] May, Bruce, 2018-12-31 [InstanceEdit:9635240] May, Bruce, 2019-01-19 [InstanceEdit:9635319] May, Bruce, 2019-01-26 [InstanceEdit:9645158] May, Bruce, 2019-05-06 [InstanceEdit:9661248] May, Bruce, 2019-09-15 [InstanceEdit:9668176] May, Bruce, 2019-11-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Eif2ak4 dimer autophosphorylates
output	[Complex:9633789] tRNA:p-T898-Eif2ak4:Gcn1:80S ribosome:mRNA [cytosol] [Mus musculus] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2019-12-10
reviewed	[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15 [InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9633849] R-MMU-9633741.3
summation	[Summation:9635237] After binding uncharged tRNA, the Eif2ak4 (Gcn2) dimer trans...
(inferredFrom)	[Reaction:9633742] EIF2AK4 (GCN2) dimer autophosphorylates [Homo sapiens]
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No pathways have been reviewed or authored by Eif2ak4 dimer autophosphorylates (9633741)