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Details on Person GCN2 phosphorylates SUI2

Class:IdReaction:9633480
_displayNameGCN2 phosphorylates SUI2
_doReleaseTRUE
_timestamp2019-11-20 13:55:51
authored[InstanceEdit:9633461] May, Bruce, 2018-12-28
catalystActivity[CatalystActivity:9633514] protein serine/threonine kinase activity of tRNA:p-T882,887-GCN2:GCN1:80S ribosome:mRNA [cytosol]
catalystActivityReference[CatalystActivityReference:9644923] protein serine/threonine kinase activity of tRNA:p-T882,887-GCN2:GCN1:80S ribosome:mRNA [cytosol] A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2
compartment[Compartment:70101] cytosol
created[InstanceEdit:9633466] May, Bruce, 2018-12-29
edited[InstanceEdit:9633461] May, Bruce, 2018-12-28
input[Complex:9633532] SUI2:SUI3:GCD11 [cytosol] [Saccharomyces cerevisiae]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9635254] Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
[LiteratureReference:9633776] The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
[LiteratureReference:9635245] Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases
[LiteratureReference:9635241] GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2
[LiteratureReference:9635244] Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase
[LiteratureReference:9633790] Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p
[LiteratureReference:9633756] A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2
modified[InstanceEdit:9635255] May, Bruce, 2019-01-19
[InstanceEdit:9644930] May, Bruce, 2019-04-28
[InstanceEdit:9661248] May, Bruce, 2019-09-15
[InstanceEdit:9668176] May, Bruce, 2019-11-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGCN2 phosphorylates SUI2
output[Complex:9633544] p-S52-SUI2:SUI3:GCD11 [cytosol] [Saccharomyces cerevisiae]
[SimpleEntity:29370] ADP [cytosol]
releaseDate2019-12-10
reviewed[InstanceEdit:9661246] Bruhat, Alain, 2019-09-15
[InstanceEdit:9668172] Staschke, Kirk A, 2019-11-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:68322] Saccharomyces cerevisiae
stableIdentifier[StableIdentifier:9633670] R-SCE-9633480.3
summation[Summation:9635247] GCN2 phosphorylates SUI2 (eIF-2 alpha subunit) on serine-52 ...
(inferredFrom)[Reaction:9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 [Homo sapiens]
[Reaction:9633504] Eif2ak4 phosphorylates Eif2s1 [Mus musculus]
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