Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person p16INK4A R80* [cytosol]

Class:IdEntityWithAccessionedSequence:9632586
_displayNamep16INK4A R80* [cytosol]
_timestamp2019-06-13 15:35:03
compartment[Compartment:70101] cytosol
created[InstanceEdit:9632589] Orlic-Milacic, Marija, 2018-12-19
crossReference[DatabaseIdentifier:9632627] COSMIC:COSM13679
[DatabaseIdentifier:9632628] COSMIC:COSV58686001
disease[Disease:1500689] cancer
[Disease:1614289] melanoma
[Disease:2327993] hepatocellular carcinoma
[Disease:8853117] lung adenocarcinoma
[Disease:1500575] ovarian cancer
[Disease:2328001] skin squamous cell carcinoma
[Disease:1248679] head and neck squamous cell carcinoma
[Disease:1493885] bladder carcinoma
[Disease:9632622] keratoacanthoma
[Disease:9632623] liposarcoma
[Disease:2327989] bile duct carcinoma
[Disease:9630851] gallbladder adenocarcinoma
[Disease:9606370] chondrosarcoma
[Disease:2362396] peripheral primitive neuroectodermal tumor
[Disease:1500576] breast cancer
[Disease:1996318] astrocytoma
[Disease:2317358] endometrial cancer
[Disease:2317476] acute lymphocytic leukemia
[Disease:9630839] acute myeloid leukemia
[Disease:9632617] diffuse large B-cell lymphoma
[Disease:9632625] follicular lymphoma
[Disease:9632624] peripheral T-cell lymphoma
[Disease:1655483] renal clear cell carcinoma
[Disease:9632629] papillary renal cell carcinoma
[Disease:1248674] large intestine cancer
[Disease:1500699] lung cancer
[Disease:1981182] lung squamous cell carcinoma
[Disease:1247848] non-small cell lung carcinoma
[Disease:9632204] Barrett's esophagus
[Disease:9632339] esophagus adenocarcinoma
[Disease:9630862] esophagus squamous cell carcinoma
[Disease:9630864] pancreatic ductal adenocarcinoma
[Disease:2327994] penis carcinoma
[Disease:1655494] prostate adenocarcinoma
[Disease:1655480] salivary gland cancer
[Disease:9632619] sebaceous carcinoma
[Disease:2328199] basal cell carcinoma
[Disease:3310977] small intestine carcinoma
[Disease:1614291] rhabdomyosarcoma
[Disease:6802256] thyroid carcinoma
[Disease:9630843] oral squamous cell carcinoma
[Disease:2328083] larynx cancer
[Disease:9632616] oral mucosa leukoplakia
[Disease:9632618] nasopharynx carcinoma
[Disease:9632101] vulva squamous cell carcinoma
endCoordinate79
hasModifiedResidue[NonsenseMutation:9649366] Nonsense mutation at L-arginine 80
literatureReference[LiteratureReference:9632578] CDKN2A/p16 is inactivated in most melanoma cell lines
[LiteratureReference:9632601] C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells
modified[InstanceEdit:9632604] Orlic-Milacic, Marija, 2018-12-19
[InstanceEdit:9632630] Orlic-Milacic, Marija, 2018-12-20
[InstanceEdit:9632635] Orlic-Milacic, Marija, 2018-12-20
[InstanceEdit:9645193] Orlic-Milacic, Marija, 2019-05-06
[InstanceEdit:9648380] Orlic-Milacic, Marija, 2019-06-06
[InstanceEdit:9649386] Orlic-Milacic, Marija, 2019-06-13
namep16INK4A R80*
p16INK4A R80TER
p16INK4A Arg80TER
p16INK4A Arg80*
CDKN2A R80TER
CDKN2A Arg80TER
CDKN2A R80*
CDKN2A Arg80*
referenceEntity[ReferenceGeneProduct:87039] UniProt:P42771 CDKN2A [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9632590] R-HSA-9632586.2
startCoordinate1
(hasMember)[CandidateSet:9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9900867] Update Tracker - [EntityWithAccessionedSequence:9632586] p16INK4A R80* [cytosol] - v70:[addHasModifiedResidue]
[Change default viewing format]
No pathways have been reviewed or authored by p16INK4A R80* [cytosol] (9632586)