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Details on Person p16INK4A P81L [cytosol]

Class:IdEntityWithAccessionedSequence:9632280
_displayNamep16INK4A P81L [cytosol]
_timestamp2019-05-06 20:21:01
compartment[Compartment:70101] cytosol
created[InstanceEdit:9632283] Orlic-Milacic, Marija, 2018-12-17
crossReference[DatabaseIdentifier:9632281] COSMIC:COSV58683884
[DatabaseIdentifier:9632286] COSMIC:COSV58718874
[DatabaseIdentifier:9632297] COSMIC:COSM1735692
disease[Disease:1500689] cancer
[Disease:1614289] melanoma
[Disease:1500576] breast cancer
[Disease:2327993] hepatocellular carcinoma
[Disease:9630864] pancreatic ductal adenocarcinoma
[Disease:2328001] skin squamous cell carcinoma
[Disease:6802256] thyroid carcinoma
[Disease:9630850] pharynx squamous cell carcinoma
[Disease:2328083] larynx cancer
[Disease:2328199] basal cell carcinoma
endCoordinate156
hasModifiedResidue[ReplacedResidue:9632282] L-proline 81 replaced with L-leucine
literatureReference[LiteratureReference:9631247] Functional reassessment of P16 variants using a transfection-based assay
modified[InstanceEdit:9632291] Orlic-Milacic, Marija, 2018-12-17
[InstanceEdit:9632303] Orlic-Milacic, Marija, 2018-12-17
[InstanceEdit:9645192] Orlic-Milacic, Marija, 2019-05-06
namep16INK4A P81L
CDKN2A P81L
CDKN2A Pro81Leu
p16INK4A Pro81Leu
referenceEntity[ReferenceGeneProduct:87039] UniProt:P42771 CDKN2A [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9632284] R-HSA-9632280.1
startCoordinate1
(hasMember)[CandidateSet:9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by p16INK4A P81L [cytosol] (9632280)