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Details on Person UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

Class:Id	Reaction:9632038
_displayName	UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG
_doRelease	TRUE
_timestamp	2025-06-11 19:59:56
authored	[InstanceEdit:159184] Jassal, B, 2005-02-23 15:02:50
catalystActivity	[CatalystActivity:9704997] glucuronosyltransferase activity of UGT1A1 tetramer [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9632042] Jassal, Bijay, 2018-12-13
edited	[InstanceEdit:827350] Jassal, B, 2010-05-27
input	[SimpleEntity:159160] BMG [endoplasmic reticulum lumen] [SimpleEntity:174384] UDP-GlcA [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:159192] The hepatic microsomal formation of bilirubin diglucuronide [LiteratureReference:159163] Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography [LiteratureReference:159173] Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver [LiteratureReference:159193] Bilirubin conjugates in bile of man and rat in the normal state and in liver disease
modified	[InstanceEdit:9704995] Jassal, Bijay, 2020-10-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
name	UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP
output	[SimpleEntity:159149] BDG [endoplasmic reticulum lumen] [SimpleEntity:158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG [Homo sapiens] [Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen [Homo sapiens] [Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate [Homo sapiens] [Reaction:9632039] UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG [Homo sapiens] [Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:699799] D'Eustachio, P, 2010-05-08
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5603394] Jassal, Bijay, 2014-07-01
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9632044] R-HSA-9632038.4
summation	[Summation:159167] The principal conjugate of bilirubin in bile is bilirubin di...
(hasEvent)	[Pathway:156588] Glucuronidation [Homo sapiens] [Pathway:189483] Heme degradation [Homo sapiens]
(normalReaction)	[FailedReaction:9036102] Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9661446] BMG, BDG translocates from ER lumen to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776555] Update Tracker - [Reaction:9632038] UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG - v75:[add_removeCatalystActivity, modifyText, removeLiteratureReference]
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