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Details on Person The ileal bile acid-binding protein (I-BABP, also known as F...
| Class:Id | Summation:9631295 |
|---|---|
| _displayName | The ileal bile acid-binding protein (I-BABP, also known as F... |
| _timestamp | 2019-01-03 19:40:38 |
| created | [InstanceEdit:9631298] Shamovsky, Veronica, 2018-12-06 |
| literatureReference | [LiteratureReference:9024460] FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene [LiteratureReference:9631289] Sterol regulatory element-binding protein-1c is responsible for cholesterol regulation of ileal bile acid-binding protein gene in vivo. Possible involvement of liver-X-receptor [LiteratureReference:9024440] Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors [LiteratureReference:9631297] Regulation of the ileal bile acid-binding protein gene: an approach to determine its physiological function(s) |
| modified | [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 |
| text | The ileal bile acid-binding protein (I-BABP, also known as FABP6) is a 14 kDa soluble bile acid (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. FABP6 gene expression was directly up-regulated by liver X-receptor α (LXRα or NR1H3) and LXRβ (NR1H2) in human enterocyte-like Caco-2 cells when the cells were transiently cotransfected with a FABP6 promoter fragment cloned upstream of the CAT reporter gene and expression vectors for NR1H3 or NR1H2 and retinoid X receptor α (RXRα) (Landrier JF et al. 2003). Electrophoretic mobility shift assays demonstrated that the NR1H3:RXR heterodimer specifically recognized a farnesoid X‐receptor‐responsive element (FXRE) which functioned as an LXR responsive element (LXRE) in the promoter of FABP6 gene (Landrier JF et al. 2003). Similar data have been reported for the PLTP gene suggesting that the FXRE sequence can function as an LXR‐binding site in different genes (Landrier JF et al. 2002). FABP6 gene expression can be also up-regulated by sterol sensors such as farnesoid X receptor (FXR, NR1H4) or sterol-responsive element-binding protein 1c (SREBP1c) (Mak PA et al. 2002; Landrier JF et al. 2002; Zaghini I et al. 2002). |
| (summation) | [Reaction:9631296] NR1H2,3 binds the FABP6 gene [Homo sapiens] |
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No pathways have been reviewed or authored by The ileal bile acid-binding protein (I-BABP, also known as F... (9631295)
