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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person p16INK4A R24P [cytosol]

Class:IdEntityWithAccessionedSequence:9630828
_displayNamep16INK4A R24P [cytosol]
_timestamp2019-05-06 20:21:08
compartment[Compartment:70101] cytosol
created[InstanceEdit:9630825] Orlic-Milacic, Marija, 2018-12-03
crossReference[DatabaseIdentifier:9630840] COSMIC:COSM36170
[DatabaseIdentifier:9630838] COSMIC:COSV58704208
disease[Disease:1614289] melanoma
[Disease:1500689] cancer
[Disease:8853117] lung adenocarcinoma
[Disease:1996318] astrocytoma
[Disease:2327993] hepatocellular carcinoma
[Disease:9630839] acute myeloid leukemia
[Disease:9630842] sarcoma
[Disease:9630843] oral squamous cell carcinoma
endCoordinate156
hasModifiedResidue[ReplacedResidue:9630829] L-arginine 24 replaced with L-proline
literatureReference[LiteratureReference:9630820] A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
[LiteratureReference:9630869] Germline mutations of the CDKN2 gene in UK melanoma families
[LiteratureReference:9630871] Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
[LiteratureReference:9631243] Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
modified[InstanceEdit:9630837] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630844] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630881] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630903] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9631330] Orlic-Milacic, Marija, 2018-12-06
[InstanceEdit:9645192] Orlic-Milacic, Marija, 2019-05-06
namep16INK4A R24P
p16INK4A Arg24Pro
referenceEntity[ReferenceGeneProduct:87039] UniProt:P42771 CDKN2A [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9630831] R-HSA-9630828.1
startCoordinate1
summation[Summation:9630834] p16INK4A R24P mutant is produced by a missense mutation in t...
(hasMember)[CandidateSet:9630826] p16INK4A LoF mutants (CDK4) [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by p16INK4A R24P [cytosol] (9630828)