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Details on Person p16INK4A mutants do not bind CDK4,CDK6

Class:IdFailedReaction:9630795
_displayNamep16INK4A mutants do not bind CDK4,CDK6
_doReleaseTRUE
_timestamp2019-06-11 19:23:54
authored[InstanceEdit:9632937] Orlic-Milacic, Marija, 2018-12-24
compartment[Compartment:70101] cytosol
created[InstanceEdit:9630793] Orlic-Milacic, Marija, 2018-12-03
disease[Disease:1500689] cancer
entityFunctionalStatus[EntityFunctionalStatus:9630819] loss_of_function of p16INK4A LoF mutants (CDK4/6) [cytosol]
input[CandidateSet:9630804] p16INK4A LoF mutants (CDK4/6) [cytosol] [Homo sapiens]
[DefinedSet:69209] CDK4,CDK6 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9630820] A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
[LiteratureReference:9630869] Germline mutations of the CDKN2 gene in UK melanoma families
[LiteratureReference:9631144] CDKN2A unclassified variants in familial malignant melanoma: combining functional and computational approaches for their assessment
[LiteratureReference:9631243] Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
[LiteratureReference:9631247] Functional reassessment of P16 variants using a transfection-based assay
[LiteratureReference:9632347] Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors
[LiteratureReference:9632507] Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information
[LiteratureReference:9632601] C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells
[LiteratureReference:9630871] Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
[LiteratureReference:9631273] Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients
[LiteratureReference:9632578] CDKN2A/p16 is inactivated in most melanoma cell lines
[LiteratureReference:9649227] Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas
[LiteratureReference:9649202] A cell cycle regulator potentially involved in genesis of many tumor types
[LiteratureReference:9649229] High frequency of p16INK4A gene alterations in hepatocellular carcinoma
[LiteratureReference:9646518] COSMIC: somatic cancer genetics at high-resolution
modified[InstanceEdit:9630821] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630824] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630914] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9631166] Orlic-Milacic, Marija, 2018-12-04
[InstanceEdit:9631245] Orlic-Milacic, Marija, 2018-12-05
[InstanceEdit:9631252] Orlic-Milacic, Marija, 2018-12-05
[InstanceEdit:9631276] Orlic-Milacic, Marija, 2018-12-05
[InstanceEdit:9631332] Orlic-Milacic, Marija, 2018-12-06
[InstanceEdit:9632076] Orlic-Milacic, Marija, 2018-12-14
[InstanceEdit:9632469] Orlic-Milacic, Marija, 2018-12-18
[InstanceEdit:9632506] Orlic-Milacic, Marija, 2018-12-19
[InstanceEdit:9632604] Orlic-Milacic, Marija, 2018-12-19
[InstanceEdit:9632719] Orlic-Milacic, Marija, 2018-12-20
[InstanceEdit:9634018] Orlic-Milacic, Marija, 2019-01-03
[InstanceEdit:9645036] Orlic-Milacic, Marija, 2019-05-02
[InstanceEdit:9645279] Orlic-Milacic, Marija, 2019-05-07
[InstanceEdit:9649232] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9649233] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9649234] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9649239] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep16INK4A mutants do not bind CDK4,CDK6
normalReaction
releaseDate2019-06-12
reviewed[InstanceEdit:9645278] Bennett, Dorothy C, 2019-04-23
[InstanceEdit:9649238] Nathan, Vaishnavi, 2019-06-03
[InstanceEdit:9649237] Hayward, Nicholas K, 2019-06-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9630799] R-HSA-9630795.3
summation[Summation:9630823] Wild type p16INK4A is able to form a complex with either CDK...
(hasEvent)[Pathway:9630794] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 [Homo sapiens]
[Pathway:9632700] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777608] Update Tracker - [FailedReaction:9630795] p16INK4A mutants do not bind CDK4,CDK6 - v70:[addLiteratureReference, modifyText]
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