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Details on Person p16INK4A mutants do not bind CDK4

Class:IdFailedReaction:9630792
_displayNamep16INK4A mutants do not bind CDK4
_doReleaseTRUE
_timestamp2019-06-11 19:23:48
authored[InstanceEdit:9632937] Orlic-Milacic, Marija, 2018-12-24
compartment[Compartment:70101] cytosol
created[InstanceEdit:9630793] Orlic-Milacic, Marija, 2018-12-03
disease[Disease:1500689] cancer
entityFunctionalStatus[EntityFunctionalStatus:9630827] loss_of_function of p16INK4A LoF mutants (CDK4) [cytosol]
input[CandidateSet:9630826] p16INK4A LoF mutants (CDK4) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:68330] CDK4 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9630820] A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
[LiteratureReference:9630869] Germline mutations of the CDKN2 gene in UK melanoma families
[LiteratureReference:9630871] Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
[LiteratureReference:9630896] Functional impairment of p16(INK4A) due to CDKN2A p.Gly23Asp missense mutation
[LiteratureReference:9631144] CDKN2A unclassified variants in familial malignant melanoma: combining functional and computational approaches for their assessment
[LiteratureReference:9631243] Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
[LiteratureReference:9631273] Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients
[LiteratureReference:9632507] Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information
[LiteratureReference:9646518] COSMIC: somatic cancer genetics at high-resolution
modified[InstanceEdit:9630832] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630837] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630881] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9630903] Orlic-Milacic, Marija, 2018-12-03
[InstanceEdit:9631148] Orlic-Milacic, Marija, 2018-12-04
[InstanceEdit:9631244] Orlic-Milacic, Marija, 2018-12-05
[InstanceEdit:9632075] Orlic-Milacic, Marija, 2018-12-14
[InstanceEdit:9632094] Orlic-Milacic, Marija, 2018-12-14
[InstanceEdit:9632561] Orlic-Milacic, Marija, 2018-12-19
[InstanceEdit:9632719] Orlic-Milacic, Marija, 2018-12-20
[InstanceEdit:9645036] Orlic-Milacic, Marija, 2019-05-02
[InstanceEdit:9645279] Orlic-Milacic, Marija, 2019-05-07
[InstanceEdit:9649234] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9649239] Orlic-Milacic, Marija, 2019-06-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep16INK4A mutants do not bind CDK4
normalReaction
releaseDate2019-06-12
reviewed[InstanceEdit:9645278] Bennett, Dorothy C, 2019-04-23
[InstanceEdit:9649238] Nathan, Vaishnavi, 2019-06-03
[InstanceEdit:9649237] Hayward, Nicholas K, 2019-06-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9630796] R-HSA-9630792.3
summation[Summation:9630835] Wild type p16INK4A is able to form a complex with either CDK...
(hasEvent)[Pathway:9630791] Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 [Homo sapiens]
[Pathway:9632697] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777570] Update Tracker - [FailedReaction:9630792] p16INK4A mutants do not bind CDK4 - v70:[addLiteratureReference, modifyText]
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