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Details on Person NTHL1 D239Y does not cleave dihydrouracil (DHU)
| Class:Id | FailedReaction:9630055 |
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| _displayName | NTHL1 D239Y does not cleave dihydrouracil (DHU) |
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| _doRelease | TRUE |
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| _timestamp | 2019-02-22 02:34:56 |
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| authored | [InstanceEdit:9632050] Orlic-Milacic, Marija, 2018-12-13 |
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| compartment | [Compartment:7660] nucleoplasm |
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| created | [InstanceEdit:9630054] Orlic-Milacic, Marija, 2018-11-27 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9635155] Orlic-Milacic, Marija, 2019-01-17 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9630231] loss_of_function of NTHL1 D239Y:DHU-dsDNA [nucleoplasm] |
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| input | [Complex:9630232] NTHL1 D239Y:DHU-dsDNA [nucleoplasm] [Homo sapiens] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9630031] Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation |
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| modified | [InstanceEdit:9630238] Orlic-Milacic, Marija, 2018-11-30
[InstanceEdit:9630254] Orlic-Milacic, Marija, 2018-11-30
[InstanceEdit:9635157] Orlic-Milacic, Marija, 2019-01-17
[InstanceEdit:9635708] Orlic-Milacic, Marija, 2019-02-07
[InstanceEdit:9637774] Orlic-Milacic, Marija, 2019-02-19
[InstanceEdit:9637990] Orlic-Milacic, Marija, 2019-02-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | NTHL1 D239Y does not cleave dihydrouracil (DHU) |
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| normalReaction |
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| releaseDate | 2019-03-20 |
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| reviewed | [InstanceEdit:9635156] Kuiper, Roland P, 2019-01-14
[InstanceEdit:9635705] Doetsch, Paul W, 2019-01-31
[InstanceEdit:9637772] Rivera Polo, Barbara, 2019-02-19
[InstanceEdit:9637988] de Voer, Richarda M, 2019-02-21 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9630057] R-HSA-9630055.2 |
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| summation | [Summation:9630251] In the NTHL1 D239Y variant, the substitution of aspartic aci... |
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| (hasEvent) | [Pathway:9630221] Defective NTHL1 substrate processing [Homo sapiens] |
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No pathways have been reviewed or authored by NTHL1 D239Y does not cleave dihydrouracil (DHU) (9630055)
