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Details on Person JMJD6 dimer hydroxylates lysine residues of U2AF2

Class:IdReaction:9630022
_displayNameJMJD6 dimer hydroxylates lysine residues of U2AF2
_doReleaseTRUE
_timestamp2023-08-08 21:00:15
authored[InstanceEdit:9631372] D'Eustachio, Peter, 2018-12-06
catalystActivity[CatalystActivity:9630016] peptidyl-lysine 5-dioxygenase activity of JMJD6 dimer [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9839951] peptidyl-lysine 5-dioxygenase activity of JMJD6 dimer [nucleoplasm] Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6)
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9630008] D'Eustachio, Peter, 2018-11-27
edited[InstanceEdit:9631372] D'Eustachio, Peter, 2018-12-06
goBiologicalProcess[GO_BiologicalProcess:5982] peptidyl-lysine hydroxylation
input[SimpleEntity:113671] 2OG [nucleoplasm]
[SimpleEntity:113671] 2OG [nucleoplasm]
[SimpleEntity:113685] O2 [nucleoplasm]
[SimpleEntity:113685] O2 [nucleoplasm]
[EntityWithAccessionedSequence:71987] U2AF2 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9841069] Matthews, Lisa, 2023-08-08
isChimericFALSE
literatureReference[LiteratureReference:4687107] JMJD6 is a histone arginine demethylase
[LiteratureReference:9630010] Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation
[LiteratureReference:9630004] Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
[LiteratureReference:9630005] Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6)
[LiteratureReference:5423067] Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
modified[InstanceEdit:9630030] D'Eustachio, Peter, 2018-11-27
[InstanceEdit:9630808] D'Eustachio, Peter, 2018-12-03
[InstanceEdit:9632429] D'Eustachio, Peter, 2018-12-17
[InstanceEdit:9632519] D'Eustachio, Peter, 2018-12-19
[InstanceEdit:9637725] D'Eustachio, Peter, 2019-02-19
[InstanceEdit:9839950] D'Eustachio, Peter, 2023-07-12
[InstanceEdit:9841068] Matthews, Lisa, 2023-08-08
nameJMJD6 dimer hydroxylates lysine residues of U2AF2
2-oxoglutarate + L-lysyl-(protein) + O2 => (5S)-5-hydroxy-L-lysyl-(protein) + CO2 + succinate
output[EntityWithAccessionedSequence:9630011] 5OHK15,276-U2AF2 [nucleoplasm] [Homo sapiens]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
releaseDate2023-09-13
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9630028] R-HSA-9630022.1
summation[Summation:9630012] Nuclear JMJD6 (JmjC domain-containing protein 6) catalyzes t...
(hasEvent)[Pathway:9629569] Protein hydroxylation [Homo sapiens]
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