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Details on Person NEIL3 cleaves oxidatively damaged guanine, in the form of 5-...
| Class:Id | Summation:9629212 |
|---|---|
| _displayName | NEIL3 cleaves oxidatively damaged guanine, in the form of 5-... |
| _timestamp | 2018-12-13 15:27:52 |
| created | [InstanceEdit:9629211] Orlic-Milacic, Marija, 2018-11-19 |
| literatureReference | [LiteratureReference:9629201] NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis [LiteratureReference:9629261] Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication [LiteratureReference:9629647] Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway |
| modified | [InstanceEdit:9629227] Orlic-Milacic, Marija, 2018-11-19 [InstanceEdit:9629228] Orlic-Milacic, Marija, 2018-11-19 [InstanceEdit:9629263] Orlic-Milacic, Marija, 2018-11-19 [InstanceEdit:9629649] Orlic-Milacic, Marija, 2018-11-22 [InstanceEdit:9632055] Orlic-Milacic, Marija, 2018-12-13 |
| text | NEIL3 cleaves oxidatively damaged guanine, in the form of 5-guanidinohydantoin (Gh), from telomeric DNA, creating and abasic (AP) site. NEIL3 expression is highest in late S phase, overlapping with telomeric DNA synthesis. NEIL3 localization at telomeres increases in response to oxidative stress. NEIL3 knockdown results in telomere dysfunction, which can lead to metaphase arrest or increased DNA bridging during anaphase. NEIL3 interacts with enzymes involved in PCNA-dependent long patch base excision repair (BER) of AP sites, but the exact mechanism of NEIL3-mediated long patch BER of damaged telomeric DNA has not been elucidated (Zhou et al. 2017). Besides telomeres, NEIL3 is also enriched in replisomes in the S phase of the cell cycle, co-localizing with RPA in replication foci (Bjoras et al. 2017). Expression of the NEIL3 gene in the S phase may be induced by E2F transcription factors, as the NEIL3 promoter contains E2F binding elements (Neurauter et al. 2012). |
| (summation) | [Reaction:9629216] NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA [Homo sapiens] |
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No pathways have been reviewed or authored by NEIL3 cleaves oxidatively damaged guanine, in the form of 5-... (9629212)
