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Details on Person Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation

Class:Id	Polymerisation:9628444
_displayName	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
_doRelease	TRUE
_timestamp	2018-11-08 19:18:02
authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:1986608] ubiquitin-protein transferase activity of viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9628445] Shamovsky, Veronica, 2018-11-08
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
output	[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex [Homo sapiens] [Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:9031716] Influenza A virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:174100] UBE2E1 [cytosol] [Homo sapiens] [Complex:202463] UBE2N:UBE2V1 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:532638] Gillespie, ME, 2010-03-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9628447] R-HSA-9628444.2
summation	[Summation:9628446] E3 ubiquitin ligase TRAF6 generates free K63 -linked polyubi...
(hasEvent)	[Pathway:9014325] TICAM1,TRAF6-dependent induction of TAK1 complex [Homo sapiens]
(precedingEvent)	[Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
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