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Details on Person XIAP binds CASP7

Class:Id	Reaction:9627107
_displayName	XIAP binds CASP7
_doRelease	TRUE
_timestamp	2019-04-18 21:41:29
authored	[InstanceEdit:9013808] Shamovsky, Veronica, 2017-07-26
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9627098] Shamovsky, Veronica, 2018-11-01
edited	[InstanceEdit:9627669] Shamovsky, Veronica, 2018-11-02
input	[EntityWithAccessionedSequence:50849] XIAP [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:50849] XIAP [cytosol] [Homo sapiens] [Complex:141643] Caspase-7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9627415] Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes [LiteratureReference:114476] Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain [LiteratureReference:9627380] Structural basis of caspase-7 inhibition by XIAP [LiteratureReference:9627388] XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
modified	[InstanceEdit:9627414] Shamovsky, Veronica, 2018-11-02 [InstanceEdit:9628204] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9628211] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9644766] Shamovsky, Veronica, 2019-04-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	XIAP binds CASP7
output	[Complex:114308] XIAP:Caspase-7 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:114261] Cleavage of Procaspase-7 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens]
regulatedBy	[NegativeRegulation:9627076] Negative regulation by 'DIABLO dimer [cytosol]'
regulationReference	[RegulationReference:9644767] Negative regulation by 'DIABLO dimer [cytosol]' A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
releaseDate	2018-12-13
reviewed	[InstanceEdit:9627969] Matthews, Lisa, 2018-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9627108] R-HSA-9627107.3
summation	[Summation:9627105] The inhibitor‑of‑apoptosis (IAP) family of proteins such as ...
(hasEvent)	[Pathway:111469] SMAC, XIAP-regulated apoptotic response [Homo sapiens]
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No pathways have been reviewed or authored by XIAP binds CASP7 (9627107)