Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Intracellular proteins are targeted for proteolytic degradat...
| Class:Id | Summation:9626052 |
|---|---|
| _displayName | Intracellular proteins are targeted for proteolytic degradat... |
| _timestamp | 2019-01-08 10:44:11 |
| created | [InstanceEdit:9626044] Varusai, Thawfeek, 2018-10-25 |
| modified | [InstanceEdit:9626112] Varusai, Thawfeek, 2018-10-25 [InstanceEdit:9626243] Varusai, Thawfeek, 2018-10-26 [InstanceEdit:9634273] Varusai, Thawfeek, 2019-01-08 |
| text | Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2). Subsequently, Lamp2 forms a multimeric complex stabilized with the aid of Hsp90 and glial fibrillary acidic protein (Gfap). This multimer allows the transfer of substrate into the lumen. The stability of this complex is regulated by the dynamics of Gfap and elongation factor 1α (Eef1a1). During autophagy, a phosphorylated version of Gfap remains bound to Eef1a1. When GTP becomes available, Eef1a1 dissociates from Gfap and binds with GTP in the cytosol (Bandyopadhyay U et al. 2010). |
| (summation) | [Reaction:9626036] Eef1a1 binds GTP [Rattus norvegicus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Intracellular proteins are targeted for proteolytic degradat... (9626052)
