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Details on Person SPHK1 phosphorylates sphingosine in response to E2 stimulation

Class:Id	Reaction:9625814
_displayName	SPHK1 phosphorylates sphingosine in response to E2 stimulation
_doRelease	TRUE
_timestamp	2019-02-19 22:14:00
authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:9625800] sphingosine kinase activity of SPHK1 [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9625815] Rothfels, Karen, 2018-10-22
input	[SimpleEntity:1606609] SPG [plasma membrane]
literatureReference	[LiteratureReference:9625797] Sphingosine kinase transmits estrogen signaling in human breast cancer cells [LiteratureReference:9625790] Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1 [LiteratureReference:9634620] Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells [LiteratureReference:9634627] Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells [LiteratureReference:9622951] Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF [LiteratureReference:9021140] Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane [LiteratureReference:9623951] Estrogen biology: new insights into GPER function and clinical opportunities
modified	[InstanceEdit:9634649] Rothfels, Karen, 2019-01-12 [InstanceEdit:9637808] Rothfels, Karen, 2019-02-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SPHK1 phosphorylates sphingosine in response to E2 stimulation
output	[SimpleEntity:5218688] S1P [plasma membrane]
precedingEvent	[Reaction:9036308] ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex [Homo sapiens] [Reaction:9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s [Homo sapiens]
regulatedBy	[PositiveRegulation:9625807] Positive regulation by 'ESTG:Me260-ESR1 dimer [cytosol]'
releaseDate	2019-03-20
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9625817] R-HSA-9625814.2
summation	[Summation:9634632] Estrogen stimulation of breast cancer cells promotes ESR1- d...
(hasEvent)	[Pathway:9009391] Extra-nuclear estrogen signaling [Homo sapiens]
(precedingEvent)	[Reaction:9625813] S1P binds S1PR3 in response to E2 stimulation [Homo sapiens]
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