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Details on Person Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride

Class:Id	Reaction:9625548
_displayName	Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride
_doRelease	TRUE
_timestamp	2018-11-07 00:16:22
authored	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
compartment	[Compartment:1222282] phagocytic vesicle lumen
created	[InstanceEdit:9625551] Shamovsky, Veronica, 2018-10-20
edited	[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
input	[SimpleEntity:6789150] HOCl [phagocytic vesicle lumen] [OtherEntity:9625549] Peptidyl-Cys-SH [phagocytic vesicle lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:9625545] Hypochlorite-induced oxidation of amino acids, peptides and proteins [LiteratureReference:6789116] Redox reactions and microbial killing in the neutrophil phagosome [LiteratureReference:9625547] Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate
modified	[InstanceEdit:9625560] Shamovsky, Veronica, 2018-10-20 [InstanceEdit:9625999] Shamovsky, Veronica, 2018-10-24 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride
output	[OtherEntity:9625544] Peptidyl-Cys-SCl [phagocytic vesicle lumen] [SimpleEntity:1222475] H2O [phagocytic vesicle lumen]
precedingEvent	[Reaction:6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) [Homo sapiens] [Reaction:6789092] NOX2 generates superoxide anion from oxygen [Homo sapiens] [Reaction:6789031] Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9628191] N�sse, Oliver, 2018-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9625553] R-HSA-9625548.2
summation	[Summation:9625542] Hypochlorous acid (HOCl) is a powerful oxidant generated fro...
(hasEvent)	[Pathway:8941413] Events associated with phagocytolytic activity of PMN cells [Homo sapiens]
(precedingEvent)	[Reaction:9625540] Cys-sulfenyl chloride is converted to Cys-sulfenic acid [Homo sapiens]
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