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Details on Person Hypochlorous acid (HOCl) is a powerful oxidant generated fro...

Class:IdSummation:9625542
_displayNameHypochlorous acid (HOCl) is a powerful oxidant generated fro...
_timestamp2018-10-23 07:15:17
created[InstanceEdit:9625551] Shamovsky, Veronica, 2018-10-20
literatureReference[LiteratureReference:6789116] Redox reactions and microbial killing in the neutrophil phagosome
[LiteratureReference:9625545] Hypochlorite-induced oxidation of amino acids, peptides and proteins
[LiteratureReference:9625546] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
[LiteratureReference:9625547] Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate
modified[InstanceEdit:9625906] Shamovsky, Veronica, 2018-10-23
textHypochlorous acid (HOCl) is a powerful oxidant generated from H2O2 and Cl- by the heme enzyme myeloperoxidase (MPO), which is released from activated leukocytes. HOCl leads to chlorination of thiol-containing cysteine (Cys) residues forming Cys-sulfenyl chloride (Cys-SCl) intermediate and then Cys-sulfenic acid (Cys-SOH), which can either form a disulfide with an adjacent thiol or be further oxidized by HOCl to generate Cys- sulfinic and Cys-sulfonic acids sequentially (Peskin AV & Winterbourn CC 2001; Hawkins CL et al. 2003; Paulsen CE & Carroll KS 2013; Winterbourn CC & Kettle AJ 2013). Disulfides function as redox switches to control protein activity and protect thiol groups against overoxidation to Cys-sulfinic and -sulfonic acids.
(summation)[Reaction:9625548] Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride [Homo sapiens]
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