Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PTK2 binds activated EGFR

Class:IdReaction:9625482
_displayNamePTK2 binds activated EGFR
_doReleaseTRUE
_timestamp2019-05-02 03:07:32
authored[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9625483] Rothfels, Karen, 2018-10-19
input[Complex:9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:201621] PTK2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9625255] FAK integrates growth-factor and integrin signals to promote cell migration
[LiteratureReference:9625274] Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
[LiteratureReference:9625310] The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway
[LiteratureReference:9625260] Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
[LiteratureReference:8984387] Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
[LiteratureReference:9625283] Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer
modified[InstanceEdit:9637808] Rothfels, Karen, 2019-02-19
[InstanceEdit:9645020] Rothfels, Karen, 2019-05-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePTK2 binds activated EGFR
output[Complex:9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2019-03-20
reviewed[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19
[InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24
[InstanceEdit:9645002] Marino, Maria, 2019-04-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9625485] R-HSA-9625482.3
summation[Summation:9625484] PTK2 (also known as FAK, focal adhesion kinase) binds to the...
(hasEvent)[Pathway:9009391] Extra-nuclear estrogen signaling [Homo sapiens]
(precedingEvent)[Reaction:9625487] PTK2 autophosphorylates downstream of EGFR [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by PTK2 binds activated EGFR (9625482)