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Details on Person FOXO1 directly represses transcription of the SREBF1 (SREBP1...

Class:IdSummation:9625349
_displayNameFOXO1 directly represses transcription of the SREBF1 (SREBP1...
_timestamp2018-10-19 15:07:12
created[InstanceEdit:9625350] Orlic-Milacic, Marija, 2018-10-19
literatureReference[LiteratureReference:9625320] FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c
[LiteratureReference:9625353] SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
[LiteratureReference:9625334] FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells
textFOXO1 directly represses transcription of the SREBF1 (SREBP1) gene, encoding Sterol regulatory element-binding protein 1, a transcriptional activator required for lipid homeostasis (Deng et al. 2012). FOXO1 binding interferes with recruitment of SREBF1 transcriptional activator NR1H3 (LXRA) to the SREBF1 promoter (Liu et al. 2010). CRY1, a transcriptional target of SREBF1, downregulates FOXO1 protein levels by promoting MDM2-mediated polyubiquitination and degradation of FOXO1 (Jang et al. 2016).
(summation)[BlackBoxEvent:9625346] SREBF1 gene expression is inhibited by FOXO1 [Homo sapiens]
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