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Details on Person Unfolded substrate in LAMP2a multimeric complex binds HSPA8

Class:Id	Reaction:9625196
_displayName	Unfolded substrate in LAMP2a multimeric complex binds HSPA8
_doRelease	TRUE
_timestamp	2019-11-12 10:05:05
authored	[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9625192] Varusai, Thawfeek, 2018-10-19
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
inferredFrom	[Reaction:9625173] Unfolded substrate in Lamp2 multimeric complex binds Hspa8 [Rattus norvegicus]
input	[Complex:9625181] LAMP2a multimer complex:GFAP [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9625182] HSPA8 [lysosomal lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9625186] A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins [LiteratureReference:9625187] An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
modified	[InstanceEdit:9625229] Varusai, Thawfeek, 2018-10-19 [InstanceEdit:9637992] Varusai, Thawfeek, 2019-02-22 [InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9667360] Varusai, Thawfeek, 2019-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Unfolded substrate in LAMP2a multimeric complex binds HSPA8
output	[Complex:9625165] HSPA8:LAMP2a multimeric complex [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:9625197] GFAP binds LAMP2a multimer [Homo sapiens] [Polymerisation:9624158] Substrate:LAMP2a:HSP90 polymerizes [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9637993] Metzakopian, Emmanouil, 2019-02-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9625207] R-HSA-9625196.3
summation	[Summation:9625161] Intracellular proteins are targeted for proteolytic degradat...
(hasEvent)	[Pathway:9613829] Chaperone Mediated Autophagy [Homo sapiens]
(precedingEvent)	[Reaction:9625188] HSPA8 transports unfolded substrate to lysosomal lumen for degradation [Homo sapiens]
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No pathways have been reviewed or authored by Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (9625196)