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Details on Person HSPA8 transports unfolded substrate to lysosomal lumen for degradation

Class:Id	Reaction:9625188
_displayName	HSPA8 transports unfolded substrate to lysosomal lumen for degradation
_doRelease	TRUE
_timestamp	2019-11-12 09:58:08
authored	[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9625192] Varusai, Thawfeek, 2018-10-19
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
inferredFrom	[Reaction:9625160] Hspa8 transports unfolded substrate to lysosomal lumen for degradation [Rattus norvegicus]
input	[Complex:9625165] HSPA8:LAMP2a multimeric complex [lysosomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9625186] A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins [LiteratureReference:9625187] An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
modified	[InstanceEdit:9625229] Varusai, Thawfeek, 2018-10-19 [InstanceEdit:9625230] Varusai, Thawfeek, 2018-10-19 [InstanceEdit:9637992] Varusai, Thawfeek, 2019-02-22 [InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05 [InstanceEdit:9667360] Varusai, Thawfeek, 2019-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HSPA8 transports unfolded substrate to lysosomal lumen for degradation
output	[Complex:9625189] HSPA8:LAMP2a multimeric complex [lysosomal membrane] [Homo sapiens]
precedingEvent	[Reaction:9625196] Unfolded substrate in LAMP2a multimeric complex binds HSPA8 [Homo sapiens] [Reaction:9625197] GFAP binds LAMP2a multimer [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9637993] Metzakopian, Emmanouil, 2019-02-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9625206] R-HSA-9625188.3
summation	[Summation:9625162] Heat shock cognate 71 kDa protein (HSPA8) translocates subst...
(hasEvent)	[Pathway:9613829] Chaperone Mediated Autophagy [Homo sapiens]
(precedingEvent)	[Reaction:9626060] HSPA8:Substrate dissociates from LAMP2a multimer [Homo sapiens]
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No pathways have been reviewed or authored by HSPA8 transports unfolded substrate to lysosomal lumen for degradation (9625188)