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Details on Person RCC1 stimulates GDP to GTP exchange on RAN

Class:Id	Reaction:9624845
_displayName	RCC1 stimulates GDP to GTP exchange on RAN
_doRelease	TRUE
_timestamp	2022-02-08 22:13:04
authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
catalystActivity	[CatalystActivity:9624844] guanyl-nucleotide exchange factor activity of RCC1 [chromosome]
compartment	[Compartment:1598585] chromosome [Compartment:70101] cytosol
created	[InstanceEdit:9624846] Orlic-Milacic, Marija, 2018-10-15
edited	[InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
input	[Complex:206617] RAN:GDP [cytosol] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9624854] GTP hydrolysis by Ran is required for nuclear envelope assembly
modified	[InstanceEdit:9624851] Orlic-Milacic, Marija, 2018-10-15 [InstanceEdit:9624855] Orlic-Milacic, Marija, 2018-10-15 [InstanceEdit:9645037] Orlic-Milacic, Marija, 2019-05-02 [InstanceEdit:9645372] Orlic-Milacic, Marija, 2019-05-10 [InstanceEdit:9667982] Orlic-Milacic, Marija, 2019-11-18 [InstanceEdit:9668545] Orlic-Milacic, Marija, 2019-11-27 [InstanceEdit:9668549] Orlic-Milacic, Marija, 2019-11-27 [InstanceEdit:9668551] Orlic-Milacic, Marija, 2019-11-27 [InstanceEdit:9676327] Orlic-Milacic, Marija, 2020-02-12 [InstanceEdit:9764075] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RCC1 stimulates GDP to GTP exchange on RAN
negativePrecedingEvent	[NegativePrecedingEvent:9764063] Futile Cycle: RAN stimulates fusion of nuclear envelope (NE) membranes
output	[Complex:180686] RAN:GTP [cytosol] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9624847] R-HSA-9624845.3
summation	[Summation:9624850] Chromatin-associated RCC1 mediates GDP to GTP exchange on RA...
(hasEvent)	[Pathway:9615933] Postmitotic nuclear pore complex (NPC) reformation [Homo sapiens]
(precedingEvent)	[Reaction:9615945] RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160 [Homo sapiens] [Reaction:9624876] RAN:GTP recruits nuclear envelope (NE) membranes [Homo sapiens]
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No pathways have been reviewed or authored by RCC1 stimulates GDP to GTP exchange on RAN (9624845)