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Details on Person CEBPA binds CDKN1A (p21)

Class:Id	Reaction:9624668
_displayName	CEBPA binds CDKN1A (p21)
_doRelease	TRUE
_timestamp	2019-03-10 13:10:50
authored	[InstanceEdit:9624665] May, Bruce, 2018-10-13
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9624669] May, Bruce, 2018-10-13
edited	[InstanceEdit:9624665] May, Bruce, 2018-10-13
input	[EntityWithAccessionedSequence:182585] CDKN1A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381289] CEBPA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9624662] CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding [LiteratureReference:9624673] CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein [LiteratureReference:9624672] Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis
modified	[InstanceEdit:9639379] May, Bruce, 2019-03-10 [InstanceEdit:9639380] May, Bruce, 2019-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CEBPA binds CDKN1A (p21)
output	[Complex:9624675] CEBPA:CDKN1A [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9622367] CEBPA mRNA is translated to yield CEBPA protein [Homo sapiens] [BlackBoxEvent:9616243] CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9624681] R-HSA-9624668.2
summation	[Summation:9624667] CEBPA interacts with CDKN1A (p21), resulting in a cooperativ...
(hasEvent)	[Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
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No pathways have been reviewed or authored by CEBPA binds CDKN1A (p21) (9624668)