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Details on Person EGF-like ligands:p-6Y EGFR dimer [plasma membrane]

Class:IdComplex:9624425
_displayNameEGF-like ligands:p-6Y EGFR dimer [plasma membrane]
_timestamp2018-10-11 15:13:13
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9624424] Rothfels, Karen, 2018-10-11
hasComponent
isChimericFALSE
nameEGF-like ligands:p-6Y EGFR dimer
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9624426] R-HSA-9624425.1
(hasComponent)[Complex:179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Homo sapiens]
[Complex:180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [Homo sapiens]
[Complex:180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Homo sapiens]
[Complex:180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [Homo sapiens]
[Complex:180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] [Homo sapiens]
[Complex:182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [Homo sapiens]
[Complex:182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Homo sapiens]
[Complex:212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] [Homo sapiens]
[Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Homo sapiens]
[Complex:9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] [Homo sapiens]
List all 12 refering instances
(input)[Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex [Homo sapiens]
[Reaction:177941] GRB2:GAB1 binds to phosphorylated EGFR [Homo sapiens]
[Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens]
[Reaction:183055] Binding of CBL to EGFR [Homo sapiens]
[Reaction:183067] Localization of CBL:GRB2 to the membrane [Homo sapiens]
[Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Homo sapiens]
[Reaction:6785705] PTPRK dephosphorylates p-6Y-EGFR [Homo sapiens]
[Reaction:9625482] PTK2 binds activated EGFR [Homo sapiens]
[Reaction:9846371] GOCAM PTPRK dephosphorylates p-6Y-EGFR [Homo sapiens]
[Reaction:9846375] GOCAM Binding of CBL to EGFR [Homo sapiens]
List all 15 refering instances
(normalEntity)[EntityFunctionalStatus:5637711] loss_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
(output)[Reaction:177934] EGFR autophosphorylation [Homo sapiens]
[Reaction:177937] Phosphorylation of EGFR by SRC kinase [Homo sapiens]
[Reaction:212713] Active PLC-gamma1 dissociates from EGFR [Homo sapiens]
[Reaction:9846388] GOCAM Phosphorylation of EGFR by SRC kinase [Homo sapiens]
[Reaction:9846397] GOCAM Active PLC-gamma1 dissociates from EGFR [Homo sapiens]
[Reaction:9846399] GOCAM EGFR autophosphorylation [Homo sapiens]
(physicalEntity)[CatalystActivity:9851164] transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
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No pathways have been reviewed or authored by EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (9624425)
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