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Details on Person Intracellular proteins are targeted for proteolytic degradat...
| Class:Id | Summation:9624155 |
|---|---|
| _displayName | Intracellular proteins are targeted for proteolytic degradat... |
| _timestamp | 2019-01-07 11:53:08 |
| created | [InstanceEdit:9624150] Varusai, Thawfeek, 2018-10-08 |
| modified | [InstanceEdit:9624163] Varusai, Thawfeek, 2018-10-08 [InstanceEdit:9634155] Varusai, Thawfeek, 2019-01-07 |
| text | Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) acts as the constitutive chaperone that binds a KFERQ-domain containing substrate in the cytosol. Consequently, the substrate:Hspa8 complex translocates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2). Subsequently, Hspa8 is released and Heat shock protein HSP 90 binds to the lysosomal luminal end of Lamp2. Binding of Hsp90 stabilizes Lamp2 to multimerize into a 700 kDa complex (Bandyopadhyay U et al. 2008). This facilitates the internalization of substrate into the lumen. |
| (summation) | [Polymerisation:9624154] Substrate:Lamp2a:Hsp90 polymerizes [Rattus norvegicus] |
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No pathways have been reviewed or authored by Intracellular proteins are targeted for proteolytic degradat... (9624155)
