Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Transcriptional regulation of granulopoiesis

Class:IdPathwayDiagram:9624086
_displayNameDiagram of Transcriptional regulation of granulopoiesis
_timestamp2019-01-10 20:36:31
created[InstanceEdit:9624087] May, Bruce, 2018-10-08
height994
modified[InstanceEdit:9624140] May, Bruce, 2018-10-08
[InstanceEdit:9624141] May, Bruce, 2018-10-08
[InstanceEdit:9624688] May, Bruce, 2018-10-14
[InstanceEdit:9626653] May, Bruce, 2018-10-29
[InstanceEdit:9626654] May, Bruce, 2018-10-29
[InstanceEdit:9626902] May, Bruce, 2018-10-30
[InstanceEdit:9626903] May, Bruce, 2018-10-30
[InstanceEdit:9634378] May, Bruce, 2019-01-09
[InstanceEdit:9634463] May, Bruce, 2019-01-10
[InstanceEdit:9634475] May, Bruce, 2019-01-10
representedPathway[Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="117" reactomeDiagramId="9624086"> <Properties> <displayName>Diagram of Transcriptional regulation of granulopoiesis</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="1" reactomeId="70101" position="726 492" bounds="10 5 1432 974" textPosition="23 935" bgColor="250 240 240" lineColor="255 153 102" insets="20 16 1416 956"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="2" /> <Component id="21" /> <Component id="64" /> <Component id="22" /> <Component id="65" /> <Component id="105" /> <Component id="103" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="2" reactomeId="7660" position="675 482" bounds="41 38 1268 889" textPosition="52 874" bgColor="250 240 240" lineColor="255 153 102" insets="49 45 1254 873"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="3" /> <Component id="4" /> <Component id="5" /> <Component id="6" /> <Component id="8" /> <Component id="9" /> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="14" /> <Component id="15" /> <Component id="16" /> <Component id="17" /> <Component id="18" /> <Component id="19" /> <Component id="20" /> <Component id="23" /> <Component id="24" /> <Component id="25" /> <Component id="26" /> <Component id="28" /> <Component id="29" /> <Component id="30" /> <Component id="31" /> <Component id="33" /> <Component id="34" /> <Component id="35" /> <Component id="36" /> <Component id="40" /> <Component id="41" /> <Component id="42" /> <Component id="45" /> <Component id="46" /> <Component id="47" /> <Component id="48" /> <Component id="53" /> <Component id="56" /> <Component id="57" /> <Component id="58" /> <Component id="59" /> <Component id="60" /> <Component id="61" /> <Component id="62" /> <Component id="63" /> <Component id="66" /> <Component id="68" /> <Component id="71" /> <Component id="69" /> <Component id="73" /> <Component id="74" /> <Component id="75" /> <Component id="77" /> <Component id="80" /> <Component id="81" /> <Component id="82" /> <Component id="86" /> <Component id="87" /> <Component id="88" /> <Component id="89" /> <Component id="90" /> <Component id="91" /> <Component id="93" /> <Component id="94" /> <Component id="95" /> <Component id="96" /> <Component id="99" /> <Component id="101" /> <Component id="107" /> <Component id="109" /> <Component id="110" /> <Component id="111" /> <Component id="112" /> <Component id="113" /> <Component id="114" /> <Component id="115" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="4" reactomeId="8865492" position="283 67" bounds="194 56 178 22" textPosition="207 57" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SPI1 gene:Nucleosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="5" reactomeId="8865503" position="282 156" bounds="256 146 53 20" textPosition="265 146"> <Properties> <displayName>SPI1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="6" reactomeId="8865496" position="158 114" bounds="61 96 194 37" textPosition="66 98" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="9" reactomeId="992697" position="546 247" bounds="523 237 46 21" textPosition="529 237"> <Properties> <displayName>MYB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="10" reactomeId="8956511" position="488 238" bounds="463 228 51 21" textPosition="470 228"> <Properties> <displayName>TAL1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="11" reactomeId="5640210" position="470 91" bounds="421 66 99 51" textPosition="428 93"> <Properties> <displayName>CEBPA gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="12" reactomeId="8865295" position="354 192" bounds="327 181 55 22" textPosition="330 181"> <Properties> <displayName>RUNX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="14" reactomeId="996735" position="417 231" bounds="388 220 59 23" textPosition="393 221"> <Properties> <displayName>GATA2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="15" reactomeId="9616216" position="356 221" bounds="334 210 44 23" textPosition="340 211"> <Properties> <displayName>FLI1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="16" reactomeId="9616212" position="675 185" bounds="605 160 140 51" textPosition="608 162" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPA gene:RUNX1:SPI1:GATA2:TAL1:FLI1:MYB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="18" reactomeId="3214972" position="948 74" bounds="922 63 52 23" textPosition="929 64"> <Properties> <displayName>LEF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="19" reactomeId="9622412" position="871 144" bounds="807 132 129 25" textPosition="811 136" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPA gene: LEF1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="21" reactomeId="9616236" position="1374 196" bounds="1318 176 112 41" textPosition="1330 186"> <Properties> <displayName>CEBPA mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="23" reactomeId="381289" position="702 254" bounds="668 242 69 24" textPosition="678 243"> <Properties> <displayName>CEBPA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="25" reactomeId="9616239" position="137 349" bounds="95 324 85 51" textPosition="95 351"> <Properties> <displayName>CEBPE gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="26" reactomeId="9616237" position="276 438" bounds="227 421 99 35" textPosition="232 421" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPE gene:CEBPA dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="29" reactomeId="381325" position="119 409" bounds="89 396 60 27" textPosition="95 399"> <Properties> <displayName>EP300</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="30" reactomeId="9617079" position="130 443" bounds="77 430 107 27" textPosition="83 433"> <Properties> <displayName>PML isoform 4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="31" reactomeId="9617082" position="146 517" bounds="84 499 124 36" textPosition="92 500" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPE gene:EP300:SPI1:PML</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="34" reactomeId="5334804" position="404 422" bounds="382 407 44 30" textPosition="385 411"> <Properties> <displayName>atRA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="35" reactomeId="9618992" position="354 382" bounds="295 365 118 34" textPosition="310 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPE gene:RARA:RXRA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="36" reactomeId="9617060" position="344 493" bounds="288 473 113 40" textPosition="290 478" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPE gene:RXRA:RARA:atRA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="41" reactomeId="9617055" position="372 705" bounds="334 680 77 51" textPosition="337 707"> <Properties> <displayName>GFI1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="42" reactomeId="9617073" position="477 784" bounds="432 765 90 39" textPosition="433 769" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GFI1 gene:CEBPA dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="46" reactomeId="9617074" position="208 707" bounds="163 682 91 51" textPosition="167 709"> <Properties> <displayName>CSF3R gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="47" reactomeId="5250643" position="283 632" bounds="260 621 46 22" textPosition="267 621"> <Properties> <displayName>DEK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="48" reactomeId="9617202" position="328 783" bounds="278 759 100 49" textPosition="284 759" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CSF3R gene:SPI1:CEPBA dimer:DEK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="53" reactomeId="8948459" position="545 706" bounds="505 681 81 51" textPosition="511 708"> <Properties> <displayName>IL6R gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableGene id="57" reactomeId="3858376" position="1091 281" bounds="1046 256 90 51" textPosition="1049 283"> <Properties> <displayName>CEBPB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="58" reactomeId="1112525" position="1042 323" bounds="967 311 150 24" textPosition="976 314" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-Y705-STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="59" reactomeId="9617200" position="1109 451" bounds="1062 425 95 53" textPosition="1061 429" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPB gene:p-Y705-STAT3 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="61" reactomeId="111911" position="1238 320" bounds="1189 300 99 41" textPosition="1189 306" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S133-CREB1 homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="62" reactomeId="9617243" position="1230 453" bounds="1181 427 98 53" textPosition="1180 431" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPB gene:p-S133-CREB1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="64" reactomeId="9617227" position="1376 538" bounds="1321 516 111 45" textPosition="1332 528"> <Properties> <displayName>CEBPB mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="66" reactomeId="381378" position="1176 599" bounds="1142 588 69 22" textPosition="1152 588"> <Properties> <displayName>CEBPB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="69" reactomeId="2127254" position="951 404" bounds="909 379 85 51" textPosition="917 406"> <Properties> <displayName>MYC gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="71" reactomeId="9617780" position="996 560" bounds="959 530 75 61" textPosition="960 528" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYC gene:E2F1:(TFDP1,TFDP2)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="74" reactomeId="9617790" position="987 724" bounds="937 700 101 48" textPosition="937 699" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYC gene:CEBPA:E2F1:(TFDP1,TFDP2)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="77" reactomeId="9617791" position="1168 744" bounds="1109 720 119 48" textPosition="1114 719" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYC gene:phospho-STAT3:CEBPB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="81" reactomeId="5640185" position="658 714" bounds="615 689 87 51" textPosition="622 716"> <Properties> <displayName>KLF5 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="82" reactomeId="9622419" position="789 774" bounds="743 756 92 37" textPosition="745 758" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>KLF5 gene:CEBPA dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="87" reactomeId="68365" position="750 574" bounds="729 563 42 23" textPosition="730 564"> <Properties> <displayName>CDK2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="88" reactomeId="9624092" position="791 688" bounds="744 677 94 22" textPosition="749 678" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPA:CDK2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="90" reactomeId="113843" position="804 573" bounds="782 562 45 22" textPosition="784 562"> <Properties> <displayName>CDK4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="91" reactomeId="9624095" position="852 723" bounds="805 712 94 22" textPosition="810 713" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPA:CDK4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="94" reactomeId="182585" position="868 567" bounds="839 556 58 23" textPosition="839 557"> <Properties> <displayName>CDKN1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="95" reactomeId="9624675" position="927 798" bounds="875 787 104 23" textPosition="876 789" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CEBPA:CDKN1A</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="96" reactomeId="9007512" position="948 454" bounds="918 429 61 51" textPosition="920 431" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>E2F1:(TFDP1,TFDP2)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="99" reactomeId="3234072" position="149 844" bounds="118 832 62 24" textPosition="125 833"> <Properties> <displayName>CEBPE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="101" reactomeId="2980932" position="451 879" bounds="426 868 50 22" textPosition="433 868"> <Properties> <displayName>GFI1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="103" reactomeId="6787734" position="296 975" bounds="265 964 63 22" textPosition="273 964"> <Properties> <displayName>CSF3R</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="105" reactomeId="197824" position="626 973" bounds="601 962 50 22" textPosition="609 962"> <Properties> <displayName>IL6R</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="107" reactomeId="188379" position="1115 854" bounds="1090 840 50 28" textPosition="1098 843"> <Properties> <displayName>MYC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="109" reactomeId="381279" position="744 864" bounds="716 852 56 24" textPosition="726 853"> <Properties> <displayName>KLF5</displayName> </Properties> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="3" reactomeId="8865505" points="282 81, 282 113, 282 143" position="282 113" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="4" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Activators> <Activator id="6" points="258 113" /> </Activators> <Properties> <displayName>SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8" reactomeId="9616214" points="537 181, 576 180, 602 181" position="576 180" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="444 217" /> <Input id="12" points="385 190" /> <Input id="5" points="312 158" /> <Input id="9" points="544 234" /> <Input id="11" points="529 68" /> <Input id="15" points="381 216" /> <Input id="10" points="497 225" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="9622386" points="870 84, 870 106, 870 129" position="870 106" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="11" points="529 68" /> <Input id="18" points="919 77" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>LEF1 binds the promoter of the CEBPA gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="9616243" points="529 68, 870 196, 1315 196" position="870 196" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="11" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> <Activators> <Activator id="16" points="748 188" /> <Activator id="19" points="870 160" /> <Activator id="23" points="736 239" /> </Activators> <Properties> <displayName>CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="22" reactomeId="9622367" points="1354 212, 1336 236, 740 253" position="1336 236" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Properties> <displayName>CEBPA mRNA is translated to yield CEBPA protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="9616241" points="279 352, 279 386, 277 418" position="279 386" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" stoichiometry="2" points="665 261" /> <Input id="25" points="189 326" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Properties> <displayName>CEBPA binds the promoter of the CEBPE gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="28" reactomeId="9617064" points="197 396, 196 462, 162 496" position="196 462" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="152 404" /> <Input id="5" points="253 157, 73 165, 73 381" /> <Input id="25" points="189 326" /> <Input id="30" points="149 427" /> </Inputs> <Outputs> <Output id="31" /> </Outputs> <Properties> <displayName>SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="33" reactomeId="9617067" points="346 419, 345 444, 344 470" position="345 444" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="34" points="379 420" /> <Input id="35" points="350 402" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Properties> <displayName>All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="9617087" points="474 695, 474 729, 475 762" position="474 729" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" stoichiometry="2" points="695 269" /> <Input id="41" points="420 682" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> <Properties> <displayName>CEBPA binds the promoter of the GFI1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="45" reactomeId="9617207" points="298 686, 329 733, 328 756" position="329 733" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5" points="253 156, 66 158, 65 579" /> <Input id="23" stoichiometry="2" points="690 269" /> <Input id="46" points="263 684" /> <Input id="47" points="286 646" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Properties> <displayName>SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="9617194" points="1139 344, 1138 383, 1120 422" position="1138 383" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="57" points="1145 258" /> <Input id="58" points="1097 338" /> </Inputs> <Outputs> <Output id="59" /> </Outputs> <Properties> <displayName>Phospho-STAT3 binds the promoter of the CEBPB gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="60" reactomeId="9617217" points="1171 345, 1179 381, 1211 424" position="1179 381" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="57" points="1145 258" /> <Input id="61" points="1186 338" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> <Properties> <displayName>Phospho-CREB1 binds the promoter of the CEBPB gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="9617209" points="1145 258, 1171 502, 1318 528" position="1171 502" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Activators> <Activator id="59" points="1141 481" /> <Activator id="62" points="1198 483" /> </Activators> <Properties> <displayName>CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="9622377" points="1356 556, 1337 582, 1214 595" position="1337 582" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="64" /> </Inputs> <Outputs> <Output id="66" /> </Outputs> <Properties> <displayName>CEBPB mRNA is translated to yield CEBPB protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="9618586" points="1000 462, 995 508, 995 527" position="995 508" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="69" points="1003 381" /> <Input id="96" points="982 458" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> <Properties> <displayName>E2F1 binds the promoter of the MYC gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="73" reactomeId="9618582" points="975 630, 977 665, 982 697" position="977 665" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="710 269" /> <Input id="71" points="986 594" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> <Properties> <displayName>CEBPA binds MYC gene:E2F1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="9618584" points="1126 659, 1126 692, 1148 717" position="1126 692" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="66" stoichiometry="2" points="1166 613" /> <Input id="58" points="1043 338, 1058 488" /> <Input id="69" points="1003 381" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Properties> <displayName>CEBPB and phospho-STAT3 bind the promoter of the MYC gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="80" reactomeId="9622363" points="731 709, 740 734, 766 753" position="740 734" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" stoichiometry="2" points="702 269" /> <Input id="81" points="711 691" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>CEBPA binds the promoter of the KLF5 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="9624120" points="781 593, 788 638, 790 674" position="788 638" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="704 269" /> <Input id="87" points="768 589" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>CEBPA binds CDK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="9624112" points="841 594, 851 642, 851 709" position="851 642" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="706 269" /> <Input id="90" points="823 587" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>CEBPA binds CDK4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="93" reactomeId="9624668" points="923 588, 926 649, 926 784" position="926 649" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="23" points="709 269" /> <Input id="94" points="900 578" /> </Inputs> <Outputs> <Output id="95" /> </Outputs> <Properties> <displayName>CEBPA binds CDKN1A (p21)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="9634433" points="189 326, 221 528, 146 679, 148 829" position="146 679" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="25" /> </Inputs> <Outputs> <Output id="99" /> </Outputs> <Activators> <Activator id="31" points="146 538" /> <Activator id="36" points="322 516" /> <Activator id="26" points="266 459" /> </Activators> <Properties> <displayName>CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="9634446" points="420 682, 427 840, 444 865" position="427 840" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="41" /> </Inputs> <Outputs> <Output id="101" /> </Outputs> <Activators> <Activator id="42" points="459 807" /> </Activators> <Properties> <displayName>GFI1 gene expression is enhanced by CEBPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="112" reactomeId="9634429" points="263 684, 267 838, 293 961" position="267 838" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="46" /> </Inputs> <Outputs> <Output id="103" /> </Outputs> <Activators> <Activator id="48" points="300 811" /> </Activators> <Properties> <displayName>CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="9634430" points="595 683, 588 819, 623 959" position="588 819" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="105" /> </Outputs> <Activators> <Activator id="23" points="699 269" /> </Activators> <Properties> <displayName>IL6R gene expression is enhanced by CEBPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="9634442" points="711 691, 713 794, 738 849" position="713 794" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="81" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Activators> <Activator id="82" points="740 786" /> </Activators> <Properties> <displayName>KLF5 gene expression is enhanced by CEBPA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="9634445" points="1003 381, 1098 780, 1111 837" position="1098 780" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="69" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> <Inhibitors> <Inhibitor id="74" points="1034 751" /> </Inhibitors> <Activators> <Activator id="77" points="1121 771" /> <Activator id="71" points="1010 594" /> </Activators> <Properties> <displayName>MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width1450
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Transcriptional regulation of granulopoiesis (9624086)
Follow Reactome