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Details on Person SHC1 is phosphorylated downstream of estrogen stimulation of GPER1

Class:Id	BlackBoxEvent:9624014
_displayName	SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
_doRelease	TRUE
_timestamp	2021-11-12 13:10:40
authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:6790063] protein tyrosine kinase activity of unknown kinase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9624015] Rothfels, Karen, 2018-10-05
edited	[InstanceEdit:9758183] Rothfels, Karen, 2021-11-09
input	[CandidateSet:9623997] SHC1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9622951] Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF [LiteratureReference:9623941] Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30 [LiteratureReference:9623955] G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein [LiteratureReference:9623966] Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway [LiteratureReference:9623969] Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases [LiteratureReference:9623961] Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology [LiteratureReference:9622966] The G-protein coupled estrogen receptor, GPER: The inside and inside-out story [LiteratureReference:9622913] A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis [LiteratureReference:9623951] Estrogen biology: new insights into GPER function and clinical opportunities
modified	[InstanceEdit:9634648] Rothfels, Karen, 2019-01-12 [InstanceEdit:9637808] Rothfels, Karen, 2019-02-19 [InstanceEdit:9637839] Rothfels, Karen, 2019-02-20 [InstanceEdit:9637950] Rothfels, Karen, 2019-02-21 [InstanceEdit:9754443] Rothfels, Karen, 2021-09-25 [InstanceEdit:9758451] Rothfels, Karen, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
output	[CandidateSet:9623990] pY-SHC1 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9036308] ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex [Homo sapiens] [Reaction:9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s [Homo sapiens]
regulatedBy	[PositiveRegulation:9624012] Positive regulation by 'G-protein beta-gamma complex [plasma membrane]' [PositiveRegulation:9624009] Positive regulation by 'MyrG-p-Y419-SRC [plasma membrane]'
releaseDate	2019-03-20
reviewed	[InstanceEdit:9645002] Marino, Maria, 2019-04-24 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9624016] R-HSA-9624014.2
summation	[Summation:9624004] E2 treatment stimulates phosphorylation of MAPK3 and MAPK1 (...
(hasEvent)	[Pathway:9634597] GPER1 signaling [Homo sapiens]
(precedingEvent)	[Reaction:9624017] p-SHC1 binds integrin alpha5beta1:fibronectin [Homo sapiens]
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No pathways have been reviewed or authored by SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (9624014)