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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person FOXO1 (Onuma et al. 2006), which can function in collaborati...

Class:IdSummation:9623191
_displayNameFOXO1 (Onuma et al. 2006), which can function in collaborati...
_timestamp2018-10-29 19:42:49
created[InstanceEdit:9623190] Orlic-Milacic, Marija, 2018-10-03
literatureReference[LiteratureReference:9623169] FoxO6 integrates insulin signaling with gluconeogenesis in the liver
[LiteratureReference:9623329] Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin
[LiteratureReference:9623236] Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
[LiteratureReference:9623392] An mRNA splice variant of the AFX gene with altered transcriptional activity
modified[InstanceEdit:9623269] Orlic-Milacic, Marija, 2018-10-03
[InstanceEdit:9623336] Orlic-Milacic, Marija, 2018-10-03
[InstanceEdit:9623397] Orlic-Milacic, Marija, 2018-10-04
[InstanceEdit:9624169] Orlic-Milacic, Marija, 2018-10-09
[InstanceEdit:9624170] Orlic-Milacic, Marija, 2018-10-09
[InstanceEdit:9624171] Orlic-Milacic, Marija, 2018-10-09
[InstanceEdit:9626733] Orlic-Milacic, Marija, 2018-10-29
textFOXO1 (Onuma et al. 2006), which can function in collaboration with PPARGC1A (PGC-1alpha) (Puigserver et al. 2003), FOXO3 (Onuma et al. 2006), FOXO4 (Yang et al. 2002) and FOXO6 (Kim et al. 2011) directly stimulate transcription of the G6PC gene, encoding Glucose-6-phosphatase. G6PC generates glucose and enables maintenance of steady glucose blood levels during fasting. FOXO6 mRNA levels increase in liver cells during fasting (Kim et al. 2011). Upregulation of G6PC expression by FOXO1 and FOXO6 is inhibited by insulin. FOXO-mediated induction of G6PC is involved in excessive endogenous glucose production and fasting hyperglycemia in diabetes (Kim et al. 2011).
(summation)[BlackBoxEvent:9623192] G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 [Homo sapiens]
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