Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Based on studies with mouse FOXO proteins, FOXO3 (Rangarajan...

Class:IdSummation:9622793
_displayNameBased on studies with mouse FOXO proteins, FOXO3 (Rangarajan...
_timestamp2018-11-09 16:16:12
created[InstanceEdit:9622776] Orlic-Milacic, Marija, 2018-10-01
literatureReference[LiteratureReference:9622777] The essential role of FoxO6 phosphorylation in aging and calorie restriction
[LiteratureReference:9622754] Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia
[LiteratureReference:9622786] Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice
[LiteratureReference:9622771] AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle
[LiteratureReference:9622764] TNF-α Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis
[LiteratureReference:9622772] Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells
[LiteratureReference:9622875] Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes
[LiteratureReference:9622885] Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
modified[InstanceEdit:9622893] Orlic-Milacic, Marija, 2018-10-02
[InstanceEdit:9624169] Orlic-Milacic, Marija, 2018-10-09
[InstanceEdit:9624387] Orlic-Milacic, Marija, 2018-10-11
[InstanceEdit:9628535] Orlic-Milacic, Marija, 2018-11-09
textBased on studies with mouse FOXO proteins, FOXO3 (Rangarajan et al. 2015, Song et al. 2016) and FOXO6 (Kim et al. 2014) bind forkhead box elements in the promoter of the CAT gene, encoding the enzyme catalase. Catalase converts hydrogen peroxide to water and oxygen, thus protecting cells from the oxidative stress. FOXO1 positively regulates CAT gene transcription (Awad et al. 2014, Liao et al. 2016, Guo et al. 2016) and is probably able to bind to forkhead box elements in the CAT gene promoter.
FOXO3-mediated upregulation of the CAT gene transcription is positively regulated by SIRT3 histone deacetylase, which deacetylates FOXO3 under conditions of oxidative stress and increases nuclear localization of FOXO3 (Sundaresan et al. 2009, Rangarajan et al. 2015, Yang et al. 2016).
(summation)[Reaction:9622737] FOXO3,FOXO6,(FOXO1) binds CAT gene promoter [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Based on studies with mouse FOXO proteins, FOXO3 (Rangarajan... (9622793)
Follow Reactome