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Details on Person Transcription of the pro-apoptotic BBC3 (PUMA) gene is direc...

Class:IdSummation:9622709
_displayNameTranscription of the pro-apoptotic BBC3 (PUMA) gene is direc...
_timestamp2018-10-01 17:48:51
created[InstanceEdit:9622677] Orlic-Milacic, Marija, 2018-10-01
literatureReference[LiteratureReference:9622686] PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01
[LiteratureReference:9622708] Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
[LiteratureReference:9617888] FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide
[LiteratureReference:9622676] Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress
[LiteratureReference:9622679] Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-β-induced tumor formation
[LiteratureReference:9622688] Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway
[LiteratureReference:9622724] CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
modified[InstanceEdit:9622723] Orlic-Milacic, Marija, 2018-10-01
[InstanceEdit:9622730] Orlic-Milacic, Marija, 2018-10-01
textTranscription of the pro-apoptotic BBC3 (PUMA) gene is directly stimulated by FOXO3 (Dudgeon et al. 2010, Fitzwalter et al. 2018). FOXO1 upregulates BBC3 transcription (Hughes et al. 2011, Liu et al. 2015, Wu et al. 2016, Liu et al. 2017), but direct binding to the BBC3 gene locus has not been demonstrated.
FOXO-mediated upregulation of BBC3 gene transcription is positively regulated by DDIT3 (CHOP) through an unknown mechanism. DDIT3 is able to bind FOXO3, but the physiological role and context of this protein complex is not known (Ghosh et al. 2012).
(summation)[BlackBoxEvent:9622667] BBC3 gene expression is stimulated by FOXO3,(FOXO1) [Homo sapiens]
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