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Details on Person CEBPA mRNA is translated to yield CEBPA protein

Class:Id	BlackBoxEvent:9622367
_displayName	CEBPA mRNA is translated to yield CEBPA protein
_doRelease	TRUE
_timestamp	2019-03-10 13:12:09
authored	[InstanceEdit:9622396] May, Bruce, 2018-09-22
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9622415] May, Bruce, 2018-09-29
edited	[InstanceEdit:9622396] May, Bruce, 2018-09-22
inferredFrom	[BlackBoxEvent:9626284] Cebpa mRNA is translated to yield Cebpa protein [Mus musculus]
input	[EntityWithAccessionedSequence:9616236] CEBPA mRNA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9622482] Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML [LiteratureReference:9622493] Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins [LiteratureReference:9622479] Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
modified	[InstanceEdit:9622495] May, Bruce, 2018-10-01 [InstanceEdit:9626292] May, Bruce, 2018-10-27 [InstanceEdit:9639379] May, Bruce, 2019-03-10 [InstanceEdit:9639380] May, Bruce, 2019-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CEBPA mRNA is translated to yield CEBPA protein
output	[EntityWithAccessionedSequence:381289] CEBPA [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9616243] CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA [Homo sapiens] [Reaction:9616214] RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9622433] R-HSA-9622367.2
summation	[Summation:9622481] In the cytosol, 80S ribosomes translate the CEBPA mRNA to yi...
(hasEvent)	[Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
(precedingEvent)	[Reaction:9616241] CEBPA binds the promoter of the CEBPE gene [Homo sapiens] [Reaction:9617087] CEBPA binds the promoter of the GFI1 gene [Homo sapiens] [Reaction:9617207] SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene [Homo sapiens] [BlackBoxEvent:9617238] CSF3R gene transcription is enhanced by SPI1 (PU.1), CEBPA, and DEK [Homo sapiens] [Reaction:9618582] CEBPA binds MYC gene:E2F1 [Homo sapiens] [BlackBoxEvent:9622360] IL6R gene transcription is enhanced by CEBPA [Homo sapiens] [Reaction:9622363] CEBPA binds the promoter of the KLF5 gene [Homo sapiens] [Reaction:9624112] CEBPA binds CDK4 [Homo sapiens] [Reaction:9624120] CEBPA binds CDK2 [Homo sapiens] [Reaction:9624668] CEBPA binds CDKN1A (p21) [Homo sapiens] List all 12 refering instances
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No pathways have been reviewed or authored by CEBPA mRNA is translated to yield CEBPA protein (9622367)