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Details on Person EGR2 and SREBF2(1-484) dimer bind HMGCR gene

Class:Id	Reaction:9621411
_displayName	EGR2 and SREBF2(1-484) dimer bind HMGCR gene
_doRelease	TRUE
_timestamp	2020-02-27 16:00:37
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9621409] Rothfels, Karen, 2018-09-26
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:2393990] HMGCR gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens] [Complex:2317550] SREBF2 dimer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1655609] Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins [LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression [LiteratureReference:9613415] Local regulation of fat metabolism in peripheral nerves [LiteratureReference:9613434] Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination [LiteratureReference:9621579] Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes
modified	[InstanceEdit:9621627] Rothfels, Karen, 2018-09-26 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2 and SREBF2(1-484) dimer bind HMGCR gene
output	[Complex:9621351] HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9621413] R-HSA-9621411.2
summation	[Summation:9621617] HMG coenzyme A reductase catalyzes a rate-limiting step in c...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9621410] HMGCR gene expression [Homo sapiens]
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No pathways have been reviewed or authored by EGR2 and SREBF2(1-484) dimer bind HMGCR gene (9621411)