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Query author contributions in Reactome

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Details on Person HMGCR gene expression

Class:IdBlackBoxEvent:9621410
_displayNameHMGCR gene expression
_doReleaseTRUE
_timestamp2020-02-27 16:00:56
authored[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment[Compartment:7660] nucleoplasm
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9621409] Rothfels, Karen, 2018-09-26
edited[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input[EntityWithAccessionedSequence:2393990] HMGCR gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9621571] Cholesterol and myelin biogenesis
[LiteratureReference:9621601] Sources of cholesterol for kidney and nerve during development
[LiteratureReference:9621591] Regenerating sciatic nerve does not utilize circulating cholesterol
[LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression
[LiteratureReference:9613415] Local regulation of fat metabolism in peripheral nerves
[LiteratureReference:9613434] Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination
[LiteratureReference:9621579] Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes
[LiteratureReference:9621585] Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells
[LiteratureReference:9621596] SREBPs: SREBP function in glia-neuron interactions
[LiteratureReference:1655563] A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
[LiteratureReference:1655609] Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
modified[InstanceEdit:9621626] Rothfels, Karen, 2018-09-26
[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25
[InstanceEdit:9664957] Rothfels, Karen, 2019-10-28
[InstanceEdit:9665683] Rothfels, Karen, 2019-10-31
[InstanceEdit:9674656] Rothfels, Karen, 2020-01-17
[InstanceEdit:9677117] Rothfels, Karen, 2020-02-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHMGCR gene expression
output[EntityWithAccessionedSequence:9621345] HMGCR [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:9621371] Positive gene expression regulation by 'HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm]'
releaseDate2020-03-17
reviewed[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9621412] R-HSA-9621410.2
summation[Summation:9621618] Cholesterol is highly enriched in the Schwann cell membrane ...
(hasEvent)[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
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No pathways have been reviewed or authored by HMGCR gene expression (9621410)
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