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Details on Person FOXO1 and FOXO3 directly stimulate transcription of the CITE...

Class:IdSummation:9621248
_displayNameFOXO1 and FOXO3 directly stimulate transcription of the CITE...
_timestamp2018-09-26 15:43:23
created[InstanceEdit:9621247] Orlic-Milacic, Marija, 2018-09-26
literatureReference[LiteratureReference:9617886] FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress
[LiteratureReference:9621237] Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells
[LiteratureReference:9621234] FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
[LiteratureReference:9620894] Differential regulation of Foxo3a target genes in erythropoiesis
textFOXO1 and FOXO3 directly stimulate transcription of the CITED2 gene, encoding a transcription factor CITED2 (also known as MRG1). In erythroid cell progenitors, FOXO3-mediated induction of CITED2 transcription may require erythropoietin-induced formation of the complex of FOXO3 and STAT5 (Bakker et al. 2007). FOXO3-mediated induction of CITED2 in response to hypoxic stress prevents HIF1-induced apoptosis (Bakker et al. 2007). Upregulation of CITED2, mediated by FOXO1 and/or FOXO3, enables survival of cardiomyocytes under oxidative stress (Sengupta et al. 2011). Vascular insulin resistance in type 2 diabetes leads to FOXO1-mediated upregulation of CITED2, which interferes with HIF-induced angiogenesis (Wang et al. 2016).
(summation)[BlackBoxEvent:9621242] CITED2 gene expression is stimulated by FOXO1,FOXO3 [Homo sapiens]
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