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Details on Person TPH1 gene expression

Class:Id	BlackBoxEvent:9621048
_displayName	TPH1 gene expression
_doRelease	TRUE
_timestamp	2020-02-27 16:06:09
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9621047] Rothfels, Karen, 2018-09-25
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:9620702] TPH1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:976258] Synthesis of serotonin by a second tryptophan hydroxylase isoform [LiteratureReference:9620956] Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function [LiteratureReference:9620983] Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels [LiteratureReference:9620966] Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes [LiteratureReference:9031578] Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation [LiteratureReference:9610764] Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells
modified	[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TPH1 gene expression
output	[EntityWithAccessionedSequence:976250] TPH1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9621032] EGR1 binds the TPH1 promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9621049] Positive gene expression regulation by 'TPH1 gene:EGR1 [nucleoplasm]'
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9621050] R-HSA-9621048.2
summation	[Summation:9621045] TPH1 (Tryptophan hydroxylase 1) is one of two tryptophan hyd...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
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No pathways have been reviewed or authored by TPH1 gene expression (9621048)