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Details on Person CaMKII, activated by NMDA receptor-mediated calcium influx, ...

Class:IdSummation:9620432
_displayNameCaMKII, activated by NMDA receptor-mediated calcium influx, ...
_timestamp2018-11-02 15:27:04
created[InstanceEdit:9620429] Orlic-Milacic, Marija, 2018-09-24
literatureReference[LiteratureReference:9618752] Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density
[LiteratureReference:9618748] Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II
[LiteratureReference:9620261] Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
[LiteratureReference:9620268] Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
[LiteratureReference:9620273] CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin
[LiteratureReference:9620431] Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
[LiteratureReference:9620277] Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1
modified[InstanceEdit:9620449] Orlic-Milacic, Marija, 2018-09-24
[InstanceEdit:9620500] Orlic-Milacic, Marija, 2018-09-24
[InstanceEdit:9624329] Orlic-Milacic, Marija, 2018-10-10
[InstanceEdit:9627705] Orlic-Milacic, Marija, 2018-11-02
textCaMKII, activated by NMDA receptor-mediated calcium influx, translocates to the postsynaptic density (PSD) by binding to the NMDA receptor and phosphorylates AMPA receptor subunit GluA1 (GRIA1, GluR1) and auxiliary proteins. CaMKII-mediated phosphorylation of AMPA receptors enhances association of AMPA the PSD proteins and increases conductance of AMPA receptors (McGlade-McCulloh et al. 1993, Mammen et al. 1997, Strack et al. 1997, Barria et al. 1997, Tomita et al. 2005, Opazo et al. 2010).
(summation)[Reaction:9618750] CaMKII phosphorylates AMPA receptor [Homo sapiens]
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