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Details on Person UniProt:O88942 Nfatc1
| Class:Id | ReferenceGeneProduct:96204 |
|---|---|
| _chainChangeLog | chain:1-717 added on Sat February 7 2015 |
| _displayName | UniProt:O88942 Nfatc1 |
| _timestamp | 2024-08-09 19:32:45 |
| chain | chain:1-717 |
| checksum | 58837C6CC085268D |
| comment | FUNCTION Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription (PubMed:9388475). Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (By similarity). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (PubMed:23990468, PubMed:26644563).SUBUNIT Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers (By similarity). Interacts with HOMER2 and HOMER3; this interaction may compete with calcineurin/PPP3CA-binding and hence prevent NFATC1 dephosphorylation and activation (By similarity). Interacts with TLE6/GRG6 (PubMed:23990468).INTERACTION Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (PubMed:21514407). The subcellular localization of NFATC plays a key role in the regulation of gene transcription (By similarity). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11 (PubMed:26644563). Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (PubMed:24039232).ALTERNATIVE PRODUCTS Expressed in the submandibular gland (at protein level) (PubMed:21435446). Expressed in basal epidermal cells (at protein level) (PubMed:19626032). Expressed in spleen, skeletal muscle and skin (PubMed:9388475). Express in the lung and thymus (PubMed:17579027, PubMed:9388475). Weakly expressed in heart, brain, liver and kidney. Not expressed in testis (PubMed:10072529). Expressed in osteoclasts (PubMed:23990468). Also expressed during TNFSF11/RANKL-induced differentiation of bone marrow-derived macrophages to osteoclasts (PubMed:23478294).DEVELOPMENTAL STAGE Expressed at low levels at 7 dpc and increases until 17 dpc. At 17 dpc, strongly expressed in thymus, lung and submandibular gland and weakly in skeletal muscle and heart (PubMed:9388475). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697).INDUCTION Induced in T-lymphocytes upon activation of the T-cell receptor (TCR) complex. Induced after addition of phorbol 12-myristate 13-acetate (PMA) (PubMed:10072529, PubMed:9388475). Induced by calcium in pre-osteoblasts and osteoblasts (PubMed:21514407). Expressed during osteoclastogenesis, its induction and activation is regulated by TNFSF11/RANKL.DOMAIN Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.DOMAIN The N-terminal transactivation domain (TAD-A) binds to and is activated by Cbp/p300. The dephosphorylated form contains two unmasked nuclear localization signals (NLS), which allow translocation of the protein to the nucleus (By similarity).PTM Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1 (By similarity).MISCELLANEOUS Produced by alternative initiation at Met-37 of isoform Alpha. |
| description | recommendedName: Nuclear factor of activated T-cells, cytoplasmic 1 shortName: NF-ATc1 shortName: NFATc1 alternativeName: NFAT transcription complex cytosolic component shortName: NF-ATc shortName evidence="21"NFATc |
| geneName | Nfatc1 Nfat2 Nfatc |
| identifier | O88942 |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative initiation Alternative splicing Cytoplasm DNA-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Nfatc1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NFAC1_MOUSE O70345 |
| sequenceLength | 717 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:150980] UniProt:O88942-2 Nfatc1 [Mus musculus] [ReferenceIsoform:239485] UniProt:O88942-3 Nfatc1 [Mus musculus] [ReferenceIsoform:401999] UniProt:O88942-1 Nfatc1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9943439] Nfatc1 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O88942 Nfatc1 (96204)
