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Details on Person UniProt:P97685 Nfasc
| Class:Id | ReferenceGeneProduct:96203 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;chain:25-1240 added on Fri February 6 2015 |
| _displayName | UniProt:P97685 Nfasc |
| _timestamp | 2023-11-03 18:31:57 |
| chain | signal peptide:1-24 chain:25-1240 |
| checksum | 636A187BC3772513 |
| comment | FUNCTION Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination.SUBUNIT Horseshoe-shaped homodimer (By similarity). Probable constituent of a NFASC/NRCAM/ankyrin G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Associates to subunit beta-1 in developing axons as early as postanatal day 5, during the period that nodes of Ranvier are forming. Isoform 2/isoform 3 is likely to interact with axonal proteins in close association with CNTNAP1. Interacts with GLDN/gliomedin. Interacts with MYOC (By similarity).SUBCELLULAR LOCATION Isoform 1 colocalizes with ankyrin G at the nodes of Ranvier. Isoform 2/ isoform 3 is a glial component of the paranodal axo-glial junction.ALTERNATIVE PRODUCTS Isoform 1 is expressed at Nodes of Ranvier while isoform 2/isoform 3 is expressed in unmyelinated axons.DEVELOPMENTAL STAGE Strongly but transiently up-regulated in oligodendrocytes at the onset of myelinogenesis. Once these last have engaged their target exons, expression declines precipitously.DOMAIN Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.PTM Isoform 2/isoform 3 is phosphorylated at P12. Dephosphorylation is required for ankyrin binding.SIMILARITY Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. |
| description | recommendedName: Neurofascin |
| geneName | Nfasc |
| identifier | P97685 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Nfasc |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NFASC_RAT P97684 Q91Z60 |
| sequenceLength | 1240 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:150973] UniProt:P97685-2 Nfasc [Rattus norvegicus] [ReferenceIsoform:150974] UniProt:P97685-3 Nfasc [Rattus norvegicus] [ReferenceIsoform:404942] UniProt:P97685-1 Nfasc [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:373632] Neurofascin [plasma membrane] [Rattus norvegicus] [EntityWithAccessionedSequence:443605] pNfasc_RAT [plasma membrane] [Rattus norvegicus] |
| (referenceSequence) | [ModifiedResidue:443602] O4'-phospho-L-tyrosine at 1212 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P97685 Nfasc (96203)
