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Details on Person EGR2 and SOX10 bind the PRX gene

Class:Id	Reaction:9619657
_displayName	EGR2 and SOX10 bind the PRX gene
_doRelease	TRUE
_timestamp	2020-02-27 16:00:28
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9619659] Rothfels, Karen, 2018-09-18
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
inferredFrom	[Reaction:9619658] Egr2 and Sox10 bind the Prx promoter [Rattus norvegicus]
input	[EntityWithAccessionedSequence:9619344] PRX gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9619308] Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy [LiteratureReference:9619283] Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping [LiteratureReference:9619292] Periaxin mutations cause recessive Dejerine-Sottas neuropathy [LiteratureReference:9619264] A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease [LiteratureReference:9619293] Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells [LiteratureReference:9614302] Krox-20 controls myelination in the peripheral nervous system [LiteratureReference:9615605] Interactions of Sox10 and Egr2 in myelin gene regulation [LiteratureReference:9618536] Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve [LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression
modified	[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2 and SOX10 bind the PRX gene
output	[Complex:9619633] PRX gene:EGR2:SOX10 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9619660] R-HSA-9619657.2
summation	[Summation:9619654] Periaxin (PRX) is a scaffolding protein that is part of a d...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9619667] PRX gene expression [Homo sapiens]
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