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Details on Person SOX10, EGR2 and NAB proteins bind the GJB1 promoter

Class:Id	Reaction:9618725
_displayName	SOX10, EGR2 and NAB proteins bind the GJB1 promoter
_doRelease	TRUE
_timestamp	2020-02-27 16:01:26
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618728] Rothfels, Karen, 2018-09-11
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:9615475] GJB1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens] [DefinedSet:9612546] NAB1,2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9618705] The human connexin32 gene is transcribed from two tissue-specific promoters [LiteratureReference:9618696] Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10 [LiteratureReference:9613103] Nab proteins are essential for peripheral nervous system myelination [LiteratureReference:9615595] Differential Sox10 genomic occupancy in myelinating glia
modified	[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOX10, EGR2 and NAB proteins bind the GJB1 promoter
output	[Complex:9618726] GJB11 gene:SOX10:EGR2:NAB1,2 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9618729] R-HSA-9618725.2
summation	[Summation:9618727] GJB1 expression is regulated by two alternate promoters in a...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9615477] GJB1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by SOX10, EGR2 and NAB proteins bind the GJB1 promoter (9618725)