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Details on Person CEBPA binds MYC gene:E2F1

Class:Id	Reaction:9618582
_displayName	CEBPA binds MYC gene:E2F1
_doRelease	TRUE
_timestamp	2019-03-10 13:11:03
authored	[InstanceEdit:9618589] May, Bruce, 2018-09-10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618578] May, Bruce, 2018-09-10
edited	[InstanceEdit:9618589] May, Bruce, 2018-09-10
inferredFrom	[Reaction:9625589] Cebpa binds Myc gene:E2f1 [Mus musculus]
input	[Complex:9617780] MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381289] CEBPA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9618580] c-Myc is a critical target for c/EBPalpha in granulopoiesis [LiteratureReference:9617810] The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells [LiteratureReference:9625595] Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation
modified	[InstanceEdit:9622436] May, Bruce, 2018-09-29 [InstanceEdit:9624069] May, Bruce, 2018-10-07 [InstanceEdit:9625598] May, Bruce, 2018-10-21 [InstanceEdit:9639379] May, Bruce, 2019-03-10 [InstanceEdit:9639380] May, Bruce, 2019-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CEBPA binds MYC gene:E2F1
output	[Complex:9617790] MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9618586] E2F1 binds the promoter of the MYC gene [Homo sapiens] [BlackBoxEvent:9622367] CEBPA mRNA is translated to yield CEBPA protein [Homo sapiens] [BlackBoxEvent:9616243] CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9618594] R-HSA-9618582.2
summation	[Summation:9624065] CEBPA interacts with E2F1 (Keeshan et al. 2003) bound to the...
(hasEvent)	[Pathway:9616222] Transcriptional regulation of granulopoiesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9617803] MYC gene transcription is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA [Homo sapiens] [BlackBoxEvent:9634445] MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA [Homo sapiens]
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No pathways have been reviewed or authored by CEBPA binds MYC gene:E2F1 (9618582)