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Details on Person EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene

Class:Id	Reaction:9618559
_displayName	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
_doRelease	TRUE
_timestamp	2020-02-27 16:00:44
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618560] Rothfels, Karen, 2018-09-07
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9615620] PMP22 Gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [DefinedSet:9618556] TEAD1:WWTR1,YAP1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9616066] EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression [LiteratureReference:9618535] Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons [LiteratureReference:9618539] Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves [LiteratureReference:9618558] Regulation of the PMP22 gene through an intronic enhancer [LiteratureReference:9618536] Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve [LiteratureReference:9618526] Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development [LiteratureReference:9618547] Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways
modified	[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
output	[Complex:9618555] PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9618562] R-HSA-9618559.2
summation	[Summation:9618557] PMP22 gene expression is regulated during peripheral nerve m...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9615626] PMP22 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (9618559)