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Details on Person ABCA1 mRNA is translated

Class:Id	BlackBoxEvent:9618479
_displayName	ABCA1 mRNA is translated
_doRelease	TRUE
_timestamp	2019-08-12 15:15:48
authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9618484] Shamovsky, Veronica, 2018-09-07
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
input	[EntityWithAccessionedSequence:9618483] ABCA1 mRNA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9609407] Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol [LiteratureReference:9618478] Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
modified	[InstanceEdit:9619758] Shamovsky, Veronica, 2018-09-18 [InstanceEdit:9624918] Shamovsky, Veronica, 2018-10-16 [InstanceEdit:9629104] Shamovsky, Veronica, 2018-11-19 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9637777] Shamovsky, Veronica, 2019-02-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658262] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCA1 mRNA is translated
output	[EntityWithAccessionedSequence:194209] ABCA1 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 [Homo sapiens] [Reaction:9024326] Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex [Homo sapiens] [Reaction:9618486] miR-26 binds to the 3'UTR of the ABCA1 mRNA [Homo sapiens] [BlackBoxEvent:9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 [Homo sapiens] [Reaction:9624925] miR-33 binds to the 3'UTR of the ABCA1 mRNA [Homo sapiens] [BlackBoxEvent:9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 [Homo sapiens] [Reaction:9657791] miR-144 binds to the 3'UTR of the ABCA1 mRNA [Homo sapiens] [BlackBoxEvent:9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9619755] Negative gene expression regulation by 'ABCA1 mRNA:miR-26 RISC [cytosol]' [NegativeGeneExpressionRegulation:9624913] Negative gene expression regulation by 'ABCA1 mRNA:miR-33 RISC [cytosol]' [NegativeGeneExpressionRegulation:9657847] Negative gene expression regulation by 'ABCA1 mRNA:miR-144 RISC [cytosol]'
regulationReference	[RegulationReference:9641516] Negative gene expression regulation by 'ABCA1 mRNA:miR-33 RISC [cytosol]' MiR-33 contributes to the regulation of cholesterol homeostasis [RegulationReference:9641820] Negative gene expression regulation by 'ABCA1 mRNA:miR-26 RISC [cytosol]' MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7 [RegulationReference:9657840] Negative gene expression regulation by 'ABCA1 mRNA:miR-144 RISC [cytosol]' MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor
releaseDate	2019-09-10
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9618488] R-HSA-9618479.2
summation	[Summation:9618482] The ATP-binding cassette sub-family A member 1 (ABCA1) mRNA ...
(hasEvent)	[Pathway:9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux [Homo sapiens]
(precedingEvent)	[Reaction:9619756] NR1H2 binds ABCA1 [Homo sapiens]
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No pathways have been reviewed or authored by ABCA1 mRNA is translated (9618479)