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Details on Person The ADP-ribosylation factor-like 4C (ARL4C or ARL7) mRNA is ...
| Class:Id | Summation:9618400 |
|---|---|
| _displayName | The ADP-ribosylation factor-like 4C (ARL4C or ARL7) mRNA is ... |
| _timestamp | 2019-08-14 04:18:10 |
| created | [InstanceEdit:9618398] Shamovsky, Veronica, 2018-09-06 |
| literatureReference | [LiteratureReference:9618474] PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane [LiteratureReference:9618458] ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export [LiteratureReference:9618471] MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7 [LiteratureReference:9618478] Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target |
| modified | [InstanceEdit:9618472] Shamovsky, Veronica, 2018-09-06 [InstanceEdit:9618484] Shamovsky, Veronica, 2018-09-07 [InstanceEdit:9619447] Shamovsky, Veronica, 2018-09-17 [InstanceEdit:9621101] Shamovsky, Veronica, 2018-09-26 [InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13 [InstanceEdit:9658427] Shamovsky, Veronica, 2019-08-14 |
| text | The ADP-ribosylation factor-like 4C (ARL4C or ARL7) mRNA is translated to yield ARL4C protein. ARL4C localizes to both the cell surface membrane and nucleus; however, a GDP-restricted mutant (Arl4c T27N) is mainly distributed in the cytoplasm (Engel T et al. 2004; Heo WD et al. 2006). Further, mutant constructs showed that effective plasma membrane targeting of ARL4C required an N-terminal myristoyl motif as well as a flexible C-terminal polybasic tail, which suggests that the two ends of the protein synergistically support cell surface targeting (Heo WD et al. 2006). Cholesterol-loading or treatment with the synthetic agonists of liver X-receptors alpha (LXRα, NR1H3) and beta (LXRβ, NR1H2), such as T0901317 or GW3965, significantly induced the expression of ARL4C in murine RAW 264.7 and human THP1 macrophage cell lines (Hong C et al. 2011; Engel T et al. 2004; Sun D et al. 2012). Similar regulation of ARL4C mRNA expression was observed in human peripheral blood-derived monocytes (Hong C et al. 2011). NR1H2 or NR1H3 stimulation ARL4C has been shown to transport cholesterol to the membrane for the ATP-binding cassette transporter A1 (ABCA1)-associated cholesterol removal (Engel T et al. 2004). Overexpression of ARL4C in HeLa cells has been shown to enhance APOA1-mediated cholesterol efflux (Engel T et al. 2004). MicroRNA miR-26 represses NR1H2,3-dependent cholesterol efflux by targeting ARL4C mRNA (Sun D et al. 2012). |
| (summation) | [BlackBoxEvent:9618405] ARL4C mRNA is translated [Homo sapiens] |
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