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Details on Person The complex of phosphorylated SMAD2/3 and SMAD4, bound to FO...
| Class:Id | Summation:9618007 |
|---|---|
| _displayName | The complex of phosphorylated SMAD2/3 and SMAD4, bound to FO... |
| _timestamp | 2018-09-01 12:08:45 |
| created | [InstanceEdit:9618008] Orlic-Milacic, Marija, 2018-08-31 |
| modified | [InstanceEdit:9618027] Orlic-Milacic, Marija, 2018-09-01 |
| text | The complex of phosphorylated SMAD2/3 and SMAD4, bound to FOXO3, binds to the promoter of the CDKN1A gene. The p-2S-SMAD2/3:SMAD4 complex bound to FOXO1 or FOXO4 can probably also bind to the CDKN1A gene promoter. FOXG1 binding to the FOXO:SMAD complex inhibits FOXO:SMAD-mediated upregulation of CDKN1A transcription. FOXG1 plays an important role in sustained proliferation of telencephalic neuroepithelial progenitor cells (Seoane et al. 2004). |
| (summation) | [Reaction:9618004] FOXO:SMAD complex binds CDKN1A gene promoter [Homo sapiens] |
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No pathways have been reviewed or authored by The complex of phosphorylated SMAD2/3 and SMAD4, bound to FO... (9618007)
