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Details on Person FOXO:SMAD complex binds CDKN1A gene promoter

Class:Id	Reaction:9618004
_displayName	FOXO:SMAD complex binds CDKN1A gene promoter
_doRelease	TRUE
_timestamp	2018-10-31 15:07:29
authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618008] Orlic-Milacic, Marija, 2018-08-31
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
input	[Complex:9618006] FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3786256] CDKN1A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9617983] Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
modified	[InstanceEdit:9618027] Orlic-Milacic, Marija, 2018-09-01 [InstanceEdit:9625982] Orlic-Milacic, Marija, 2018-10-23 [InstanceEdit:9626979] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9626982] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9626997] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9627002] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9627006] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9627017] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FOXO:SMAD complex binds CDKN1A gene promoter
output	[Complex:9618005] FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4:CDKN1A gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 [Homo sapiens] [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens]
regulatedBy	[NegativeRegulation:9618022] Negative regulation by 'FOXG1 [nucleoplasm]'
releaseDate	2018-12-13
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9618009] R-HSA-9618004.2
summation	[Summation:9618007] The complex of phosphorylated SMAD2/3 and SMAD4, bound to FO...
(hasEvent)	[Pathway:9617828] FOXO-mediated transcription of cell cycle genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9617838] CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 [Homo sapiens]
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No pathways have been reviewed or authored by FOXO:SMAD complex binds CDKN1A gene promoter (9618004)