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Details on Person FOXO3 binds forkhead box elements in the promoter region of ...

Class:IdSummation:9617966
_displayNameFOXO3 binds forkhead box elements in the promoter region of ...
_timestamp2018-10-02 13:53:30
created[InstanceEdit:9617967] Orlic-Milacic, Marija, 2018-08-31
literatureReference[LiteratureReference:9622754] Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia
[LiteratureReference:9617975] Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
[LiteratureReference:9622885] Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
[LiteratureReference:9622875] Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes
modified[InstanceEdit:9622888] Orlic-Milacic, Marija, 2018-10-02
textFOXO3 binds forkhead box elements in the promoter region of the SOD2 gene, encoding mitochondrial manganese-dependent superoxide dismutase (Kops et al. 2002). FOXO3-mediated upregulation of the SOD2 gene transcription is positively regulated by SIRT3 histone deacetylase, which deacetylates FOXO3 under conditions of oxidative stress and increases nuclear localization of FOXO3 (Sundaresan et al. 2009, Rangarajan et al. 2015, Yang et al. 2016).
(summation)[Reaction:9617972] FOXO3 binds SOD2 gene promoter [Homo sapiens]
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