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Details on Person Myc gene transcription is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa

Class:Id	BlackBoxEvent:9617783
_displayName	Myc gene transcription is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa
_timestamp	2018-10-30 04:50:07
authored	[InstanceEdit:9617647] May, Bruce, 2018-08-30
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9617787] May, Bruce, 2018-08-30
edited	[InstanceEdit:9617647] May, Bruce, 2018-08-30
input	[EntityWithAccessionedSequence:9617795] Myc gene [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9617221] STAT3 controls myeloid progenitor growth during emergency granulopoiesis [LiteratureReference:9617802] E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo [LiteratureReference:9617800] Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA [LiteratureReference:9624142] Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
modified	[InstanceEdit:9624069] May, Bruce, 2018-10-07 [InstanceEdit:9624082] May, Bruce, 2018-10-07 [InstanceEdit:9624148] May, Bruce, 2018-10-08 [InstanceEdit:9624689] May, Bruce, 2018-10-14 [InstanceEdit:9626903] May, Bruce, 2018-10-30 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	Myc gene transcription is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa
output	[EntityWithAccessionedSequence:9617786] Myc mRNA isoform 201 [cytosol] [Mus musculus]
regulatedBy	[PositiveGeneExpressionRegulation:9617779] Positive gene expression regulation by 'Myc gene:Cebpb dimer:p-Y705-Stat3 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9617793] Positive gene expression regulation by 'Myc gene:E2f1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9617804] Negative gene expression regulation by 'Myc gene:E2f1:Cebpa [nucleoplasm]'
regulationReference	[RegulationReference:9641438] Positive gene expression regulation by 'Myc gene:Cebpb dimer:p-Y705-Stat3 dimer [nucleoplasm]' STAT3 controls myeloid progenitor growth during emergency granulopoiesis [RegulationReference:9642546] Positive gene expression regulation by 'Myc gene:E2f1 [nucleoplasm]' E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo [RegulationReference:9642796] Negative gene expression regulation by 'Myc gene:E2f1:Cebpa [nucleoplasm]' E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9617815] R-MMU-9617783.1
summation	[Summation:9624074] E2f1, phospho-Stat3, and Cebpb bind the promoter of the Myc ...
(inferredFrom)	[BlackBoxEvent:9617803] MYC gene transcription is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA [Homo sapiens]
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